Analysis of TNFAIP3, IRAK1, and TLR4 Gene Polymorphisms in Patients With Rheumatoid Arthritis.

OBJECTIVE

Rheumatoid arthritis (RA) arises from a complex interplay of polygenic susceptibility, epigenetic factors, and environmental modifiers. This study investigated the correlation between RA and Tumor necrosis factor α-induced protein 3 (TNFAIP3), Interleukin-1 receptor-associated kinase 1 (IRAK1), and Toll-like receptor 4 (TLR4) gene polymorphisms.

METHODS

A sample of 308 RA cases and 310 matched controls was included. Genotyping of the TNFAIP3, IRAK1, and TLR4 was performed via mass spectrometry.

RESULTS

Compared to healthy controls, individuals carrying the rs1059703 A allele (odds ratio (OR) = 0.640, 95% confidence interval (CI): 0.458-0.895, p = 0.009) of IRAK1, individuals carrying the rs5029930 C allele (OR = 0.469, 95% CI: 0.298-0.739, p = 0.001), and AC genotype (OR = 0.427, 95% CI: 0.255-0.716, p = 0.001) of TNFAIP3 had a lower RA risk. Individuals carrying the rs5029939 C allele (OR = 2.401, 95% CI: 1.436-4.017, p = 0.001) of TNFAIP3, individuals carrying the rs7873784 C allele (OR = 1.549, 95% CI: 1.101-2.179, p = 0.012), and CG genotype (OR = 1.489, 95% CI: 1.011-2.193, p = 0.043) of TLR4 had a higher RA risk.

CONCLUSION

In summary, the TNFAIP3, IRAK1, and TLR4 gene polymorphisms are associated with RA susceptibility.