European journal of ophthalmology · 2007
Serum prolactin levels and Behçet disease.
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Proença H, Ferreira C, Miranda M, Castanheira-Dinis A, Monteiro-Grillo M
Аннотация
PURPOSE: To evaluate serum prolactin levels in Behçet disease (BD) and correlate with phenotypic expression of the disease.
METHODS: This was a prospective, nonrandomized comparative trial. Twenty-two patients fulfilling BD Research Committee criteria and 21 healthy control subjects were included. Patients were classified in complete-type or incomplete-type BD subgroups according to clinical characteristics such as recurrent oral ulcers, genital ulcers, skin lesions, and ocular disease. Age, sex, HLA phenotyping, and therapy were recorded for comparative analysis between groups. Serum prolactin levels were determined by electrochemiluminescence immunoassay on a Modular Analytics E170 analyzer.
RESULTS: Prolactinemia was significantly higher (mean=19.34 ng/mL) in BD patients vs controls (mean=9.83 ng/mL) (p=0.009). This value was also statistically higher in complete-type BD sub-group vs controls (p=0.02). Younger patients (<30 y) required corticosteroids plus immunosuppressives more often (75%), suggesting an association between age and disease severity, al-though not statistically significant.
CONCLUSIONS: Results suggest the role of prolactin in BD pathogenesis and its association with disease expression, especially in complete-type BD.
METHODS: This was a prospective, nonrandomized comparative trial. Twenty-two patients fulfilling BD Research Committee criteria and 21 healthy control subjects were included. Patients were classified in complete-type or incomplete-type BD subgroups according to clinical characteristics such as recurrent oral ulcers, genital ulcers, skin lesions, and ocular disease. Age, sex, HLA phenotyping, and therapy were recorded for comparative analysis between groups. Serum prolactin levels were determined by electrochemiluminescence immunoassay on a Modular Analytics E170 analyzer.
RESULTS: Prolactinemia was significantly higher (mean=19.34 ng/mL) in BD patients vs controls (mean=9.83 ng/mL) (p=0.009). This value was also statistically higher in complete-type BD sub-group vs controls (p=0.02). Younger patients (<30 y) required corticosteroids plus immunosuppressives more often (75%), suggesting an association between age and disease severity, al-though not statistically significant.
CONCLUSIONS: Results suggest the role of prolactin in BD pathogenesis and its association with disease expression, especially in complete-type BD.