Internal medicine (Tokyo, Japan) · 2023
Overlapping Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy with Mutation in CFI in a Japanese Patient: A Case Report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Osawa Kosuke, Yamamoto Shuto, Yamano Yukiko, Kita Ayako, Okamoto Kota, Kato Noritoshi, Tatematsu Yoshitaka, Kojima Fumiyoshi, Ohya Masaki, Hara Shigeo, Murata Shin-Ichi, Inoue Norimitsu, Maruyama Shoichi, Araki Shin-Ichi
Аннотация
A 34-year-old Japanese man presented with blurred vision, headache, nausea, anemia, thrombocytopenia, and severe renal dysfunction. Thrombotic microangiopathy was initially suspected to have been caused by malignant hypertension. Antihypertensive medications did not improve his thrombocytopenia or renal dysfunction, and other diseases causing thrombotic microangiopathy were ruled out. Therefore, the patient was diagnosed with atypical hemolytic uremic syndrome. A renal biopsy revealed an overlap of thrombotic microangiopathy and C3 glomerulopathy. Genetic testing revealed c.848A>G (p.Asp283Gly), a missense heterozygous variant in the gene encoding complement factor I. Overlapping atypical hemolytic uremic syndrome and C3 glomerulopathy with complement factor I mutation is very rare, especially in Japan.