Photodynamic Effect of Bioactive Titanium Metal Initiated by X-Ray and Its Potential Application for Bone Tumor Treatment.

Bioactive titanium metals with titania/titanate surface were prepared with anodic oxidation, alkali heat, or acid-base treatment methods. It was found that the bioactive Ti could be initiated with a photodynamic effect by X-ray used for bone tumor treatment, which could produce a large amount of reactive oxygen species (ROS). This effect could affect the ROS balance of bone tumor cells, cause oxidative stress in the bone tumor cells, and promote apoptosis of bone tumor cells. In the animal test, it was found that the photodynamic therapy (PDT) of the bioactive Ti metal could inhibit bone tumor growth, which implies that the bioactive Ti metal could be endowed with anti-tumor properties during the X-ray therapeutic process. It is hopeful to get Ti metal with synergistic bio-functions with both bioactivity and anti-tumor properties by surface modification.