Current osteoporosis reports · 2026
Time-Lapse HR-pQCT: an in Vivo Imaging-Based Assessment of Bone Remodeling Dynamics.
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Zhou Minhao, Nickolas Thomas L, Ix Joachim H, Kazakia Galateia J
Аннотация
PURPOSE OF REVIEW: Osteoporosis remains a pressing worldwide health concern. Understanding disease progression and evaluating treatment responses requires comprehensive skeletal assessment. This review presents a novel skeletal assessment - time-lapse high-resolution peripheral quantitative computed tomography (time-lapse HR-pQCT) - and highlights its capability in assessing bone formation and resorption.
RECENT FINDINGS: Time-lapse analysis was validated for in vivo bone remodeling assessment in micro-CT-based preclinical studies two decades ago. Recently, clinical time-lapse HR-pQCT research has demonstrated its feasibility in assessing bone turnover in patients with chronic kidney disease, and in characterizing the spatial distribution of long-term bone gain and loss in response to medications, mechanical loading, disease, and injury. Moving forward, time-lapse HR-pQCT requires validation against the gold standard bone biopsy with quantitative histomorphometry. Time-lapse HR-pQCT is a skeletal assessment capable of evaluating and longitudinally monitoring changes in bone density, microarchitecture, and remodeling dynamics. Rigorous validation and application to clinical imaging modalities will enable its broader implementation.
RECENT FINDINGS: Time-lapse analysis was validated for in vivo bone remodeling assessment in micro-CT-based preclinical studies two decades ago. Recently, clinical time-lapse HR-pQCT research has demonstrated its feasibility in assessing bone turnover in patients with chronic kidney disease, and in characterizing the spatial distribution of long-term bone gain and loss in response to medications, mechanical loading, disease, and injury. Moving forward, time-lapse HR-pQCT requires validation against the gold standard bone biopsy with quantitative histomorphometry. Time-lapse HR-pQCT is a skeletal assessment capable of evaluating and longitudinally monitoring changes in bone density, microarchitecture, and remodeling dynamics. Rigorous validation and application to clinical imaging modalities will enable its broader implementation.