Продольная оценка когнитивной функции у пациентов с невосстановительным заболеванием, связанным с MOG-IgG.
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Risi Mario, Altieri Manuela, Bisecco Alvino, Rippa Valentina, Borgo Riccardo Maria, Maggi Gianpaolo, Cirillo Mario, d'Ambrosio Alessandro, Gallo Antonio
Аннотация
Оригинал публикации
Longitudinal assessment of cognitive function in patients with non-relapsing MOG-IgG associated disease.
BACKGROUND: Non-relapsing myelin oligodendrocyte glycoprotein antibody-associated disease (nr-MOGAD) is an inflammatory demyelinating disorder of the central nervous system that frequently affects younger populations. The longitudinal impact of nr-MOGAD on cognitive function remains poorly characterized.
OBJECTIVES: To investigate cognitive profiles and longitudinal cognitive changes in patients with nr-MOGAD compared to individuals with Relapsing-Remitting Multiple Sclerosis (pwRRMS) and healthy controls (HCs).
METHODS: A cohort of 8 nr-MOGAD patients, 32 pwRRMS patients, and 22 HCs underwent a baseline and a 12-month follow-up assessment with the Brief Repeatable Battery of Neuropsychological Tests (BRBN) and Stroop test.
RESULTS: At baseline, nr-MOGAD patients exhibited moderate cognitive deficits, particularly in verbal memory and processing speed domains, with scores intermediate between pwRRMS and HCs. At follow-up, nr-MOGAD patients, especially those with pediatric-onset, showed significant cognitive recovery, contrasting with the stable impairments observed in pwRRMS.
CONCLUSIONS: Cognitive impairment patterns in nr-MOGAD are distinct from those observed in pwRRMS and, particularly in younger patients, show a frequent reversal unlike pwRRMS, in which persistently impaired cognitive performances are much more common.