International journal of clinical and experimental pathology · 2013
Effects of human bone marrow mesenchymal stem cells on burn injury healing in a mouse model.
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Xue Liang, Xu Ying-Bin, Xie Ju-Lin, Tang Jin-Ming, Shu Bin, Chen Lei, Qi Shao-Hai, Liu Xu-Sheng
Аннотация
OBJECTIVE: To investigate the feasibility and safety of human bone marrow mesenchymal stem cells (BM-MSCs) transplantation on the improvement of burn wound healing.
METHOD: Human BM-MSCs were injected into the skin of the mouse models, and the new blood vessels growth, the engraftment of BM-MSCs and the speed of healing were observed. Moreover the body weight and activity were tested after BM-MSCs transplantation.
RESULTS: We found that wound surface healing was significantly accelerated when BM-MSCs were applied to the wound surface in mice. Moreover, both the number and density of new blood vessels were increased in the BM-MSC-treated group. The engraftment of BM-MSCs was also investigated using GFP-labeled cells and no GFP-positive cells were observed in tissues other than the location of BM-MSC injection. We also found that both body weight and activity were quickly restored in BM-MSC-treated mice, and no tumor growth was found.
CONCLUSION: The present results suggest that BM-MSC transplantation can effectively improve wound healing in a mouse model of burn injuries. Use of BM-MSCs might therefore facilitate development and improvement of burn injury treatments in future.
METHOD: Human BM-MSCs were injected into the skin of the mouse models, and the new blood vessels growth, the engraftment of BM-MSCs and the speed of healing were observed. Moreover the body weight and activity were tested after BM-MSCs transplantation.
RESULTS: We found that wound surface healing was significantly accelerated when BM-MSCs were applied to the wound surface in mice. Moreover, both the number and density of new blood vessels were increased in the BM-MSC-treated group. The engraftment of BM-MSCs was also investigated using GFP-labeled cells and no GFP-positive cells were observed in tissues other than the location of BM-MSC injection. We also found that both body weight and activity were quickly restored in BM-MSC-treated mice, and no tumor growth was found.
CONCLUSION: The present results suggest that BM-MSC transplantation can effectively improve wound healing in a mouse model of burn injuries. Use of BM-MSCs might therefore facilitate development and improvement of burn injury treatments in future.
Предметные рубрики MeSH
AnimalsBurnsCells, CulturedDisease Models, AnimalFeasibility StudiesGenes, ReporterGreen Fluorescent ProteinsHumansInjections, IntradermalMaleMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMiceMice, Inbred ICRNeovascularization, PhysiologicSkinTime FactorsTransfectionWeight GainWound Healing