Translational andrology and urology · 2026
Mixed epithelial and stromal tumor of the kidney: a case series of clinical diversity in atypical presentations.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Li Yan, Ren Xiang, Zhang Xiaoyan, Xu Tong, Wang Guohui, Qi Ruochen, Han Shichao, Ma Shuaijun
Аннотация
BACKGROUND: This study explores the clinicopathological features, diagnostic criteria, treatments, and prognosis of mixed epithelial and stromal tumor of the kidney (MESTK), with a focus on atypical cases (males and young females)-filling the gap in the perception that "only perimenopausal women are susceptible" in MESTK epidemiological data.
CASE DESCRIPTION: A retrospective analysis of 4 MESTK patients (admitted between January 2019 and December 2024) was conducted, including epidemiological data, imaging findings, pathology, immunohistochemistry (IHC), treatments, and follow-up outcomes. This analysis was combined with a literature review to summarize diagnostic and treatment patterns. Among the 4 patients, 3 were male (21, 29, and 54 years old) and 1 was female (22 years old). All were asymptomatic except 1, who reported occasional low back pain; the tumors were detected incidentally in all cases. Imaging showed cystic or cystic-solid masses (3 classified as Bosniak IIF; 1 with fat density). Pathologically, all tumors exhibited biphasic epithelial-stromal differentiation. Immunohistochemically, epithelial components expressed paired box gene 8 (Pax-8) and cytokeratin 7 (CK7); stromal components expressed estrogen receptor (ER) and progesterone receptor (PR). All patients underwent robot-assisted laparoscopic partial nephrectomy; postoperatively, physician assessment showed no significant decline in renal function, and patients reported no discomfort such as low back pain, with uneventful follow-ups.
CONCLUSIONS: MESTK presents diverse clinical features, and male or young patients are not rare. Diagnosis requires integration of non-specific imaging findings with pathological and immunohistochemical examination (positive biphasic markers). Robot-assisted partial nephrectomy is effective, and benign cases have a good prognosis. This study enriches MESTK clinical data, aiding in the differentiation of atypical cases and providing clinical evidence for standardized diagnosis and minimally invasive treatment of such cases.
CASE DESCRIPTION: A retrospective analysis of 4 MESTK patients (admitted between January 2019 and December 2024) was conducted, including epidemiological data, imaging findings, pathology, immunohistochemistry (IHC), treatments, and follow-up outcomes. This analysis was combined with a literature review to summarize diagnostic and treatment patterns. Among the 4 patients, 3 were male (21, 29, and 54 years old) and 1 was female (22 years old). All were asymptomatic except 1, who reported occasional low back pain; the tumors were detected incidentally in all cases. Imaging showed cystic or cystic-solid masses (3 classified as Bosniak IIF; 1 with fat density). Pathologically, all tumors exhibited biphasic epithelial-stromal differentiation. Immunohistochemically, epithelial components expressed paired box gene 8 (Pax-8) and cytokeratin 7 (CK7); stromal components expressed estrogen receptor (ER) and progesterone receptor (PR). All patients underwent robot-assisted laparoscopic partial nephrectomy; postoperatively, physician assessment showed no significant decline in renal function, and patients reported no discomfort such as low back pain, with uneventful follow-ups.
CONCLUSIONS: MESTK presents diverse clinical features, and male or young patients are not rare. Diagnosis requires integration of non-specific imaging findings with pathological and immunohistochemical examination (positive biphasic markers). Robot-assisted partial nephrectomy is effective, and benign cases have a good prognosis. This study enriches MESTK clinical data, aiding in the differentiation of atypical cases and providing clinical evidence for standardized diagnosis and minimally invasive treatment of such cases.