Reumatismo · 2005
[Biologic therapy with anti-TNFα in spondyloarthritides and other autoimmune diseases].
Сравнительное исследованиеАннотация на английскомСтатьяОбзорНазвание и аннотация: Перевод в очереди
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Lapadula G
Аннотация
OBJECTIVE: To evaluate the efficacy of the anti-TNFα (Tumor Necrosis Factor alpha) drugs in a variety of pathologic conditions such as psoriatic arthritis, undifferentiated entheso-arthritides, chronic inflammatory bowel diseases, adult onset Still's disease, Behcet disease.
METHODS: Review of all published studies evaluating the efficacy of these drugs (mainly infliximab and etanercept, adalimumab to a lesser degree) on the above diseases.
RESULTS: Results are reported for each pathologic condition. Both drugs showed to be very efficacious in all the above conditions, except Crohn disease where etanercept does not seem adequate.
CONCLUSIONS: Both drugs work extremely well, even though comparison between infliximab and etanercept efficacy cannot be performed, due to the lack of a direct comparison.
METHODS: Review of all published studies evaluating the efficacy of these drugs (mainly infliximab and etanercept, adalimumab to a lesser degree) on the above diseases.
RESULTS: Results are reported for each pathologic condition. Both drugs showed to be very efficacious in all the above conditions, except Crohn disease where etanercept does not seem adequate.
CONCLUSIONS: Both drugs work extremely well, even though comparison between infliximab and etanercept efficacy cannot be performed, due to the lack of a direct comparison.
Предметные рубрики MeSH
AdalimumabAdrenal Cortex HormonesAnti-Inflammatory Agents, Non-SteroidalAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntirheumatic AgentsArthritis, PsoriaticAutoimmune DiseasesBehcet SyndromeBiological TherapyClinical Trials as TopicCrohn DiseaseDouble-Blind MethodEtanerceptHumansImmunoglobulin GImmunosuppressive AgentsInfliximabMulticenter Studies as TopicRandomized Controlled Trials as TopicReceptors, Tumor Necrosis FactorReceptors, Tumor Necrosis Factor, Type IISpondylarthritisTreatment OutcomeTumor Necrosis Factor-alpha