Различия в клинических фенотипах, лабораторных и фотографических проявлениях между AQP4 и AQP4 MOG IgG двойной отрицательной NMOSD: как правильно диагностировать эти два вида.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Chu Fengna, Shi Mingchao, Zhu Jie
Аннотация
Оригинал публикации
Differences in clinical phenotype, laboratory, and imaging manifestations between AQP4 IgG positive and AQP4 MOG IgG double negative NMOSD: How to correctly diagnose the two.
Neuromyelitis optica spectrum disorders (NMOSD) is an uncommon autoimmune inflammatory demyelinating disorder of the central nervous system (CNS) and causes severe disability and even death. Aquaporin-4 immunoglobulin G (AQP4-IgG) antibody has been confirmed as the key pathogenic factor for development of NMOSD and leading to repeatting acute attacks. However, 20-40 % of NMOSD patients lack both AQP4-IgG and anti-myelin oligodendrocytes glycoproteins (MOG) IgG, in which the pathogenic factor is still unclear. There are differences in clinical, laboretory and imaiging minifestations between AQP4-IgG positive (AQP4-IgG+) and AQP4-IgG/MOG-IgG double negative (AQP4-IgG-) NMOSD. Although the treatments applied in NMOSD have made great progress, all treatments are failed in AQP4-IgG- patients. Additionally, it is hard to identify NMOSD with AQP4-IgG- from multiple sclerosis (MS). Therefore, it is suspected and challenged that AQP4-IgG could not be the only pathogenic factor in NMOSD or NMOSD with AQP4-IgG- may be a separate disorder independent of NMOSD AQP4-IgG+? It is necessary to find more pathogenic factors and to explore the new pathogenesis and treatments of NMOSD with AQP4-IgG- in the future, which has been a serious problem to be addressed by the neurology community.