Epigenomics · 2023
Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis.
МетаанализСтатьяОбзорПоддержка исследования: вне правительства СШАПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Schellhas Laura, Monasso Giulietta S, Felix Janine F, Jaddoe Vincent Wv, Huang Peiyuan, Fernández-Barrés Sílvia, Vrijheid Martine, Pesce Giancarlo, Annesi-Maesano Isabella, Page Christian M, Brantsæter Anne-Lise, Bekkhus Mona, Håberg Siri E, London Stephanie J, Munafò Marcus R, Zuccolo Luisa, Sharp Gemma C
Аннотация
Background: Prenatal caffeine exposure may influence offspring health via DNA methylation, but no large studies have tested this. Materials & methods: Epigenome-wide association studies and differentially methylated regions in cord blood (450k or EPIC Illumina arrays) were meta-analyzed across six European cohorts (n = 3725). Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea and cola was compared with assess whether caffeine is driving effects. Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. A total of 12-22 differentially methylated regions were detected with limited overlap across caffeinated beverages. Conclusion: We found little evidence to support an intrauterine effect of caffeine on offspring DNA methylation. Statistical power limitations may have impacted our findings.