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DOI 10.1021/acs.est.3c00159

Медицинская библиотека · Environmental science & technology · 2023

Toward a Universal Unit for Quantification of Antibiotic Resistance Genes in Environmental Samples.

Yin Xiaole, Chen Xi, Jiang Xiao-Tao, Yang Ying, Li Bing, Shum Marcus Ho-Hin, Lam Tommy T Y, Leung Gabriel M, Rose Joan, Sanchez-Cid Concepcion, Vogel Timothy M, Walsh Fiona, Berendonk Thomas U, Midega Janet, Uchea Chibuzor, Frigon Dominic, Wright Gerard D, Bezuidenhout Carlos, Picão Renata C, Ahammad Shaikh Z, Nielsen Per Halkjær, Hugenholtz Philip, Ashbolt Nicholas J, Corno Gianluca, Fatta-Kassinos Despo, Bürgmann Helmut, Schmitt Heike, Cha Chang-Jun, Pruden Amy, Smalla Kornelia, Cytryn Eddie, Zhang Yu, Yang Min, Zhu Yong-Guan, Dechesne Arnaud, Smets Barth F, Graham David W, Gillings Michael R, Gaze William H, Manaia Célia M, van Loosdrecht Mark C M, Alvarez Pedro J J, Blaser Martin J, Tiedje James M, Topp Edward, Zhang Tong

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

Surveillance of antibiotic resistance genes (ARGs) has been increasingly conducted in environmental sectors to complement the surveys in human and animal sectors under the "One-Health" framework. However, there are substantial challenges in comparing and synthesizing the results of multiple studies that employ different test methods and approaches in bioinformatic analysis. In this article, we consider the commonly used quantification units (ARG copy per cell, ARG copy per genome, ARG density, ARG copy per 16S rRNA gene, RPKM, coverage, PPM, etc.) for profiling ARGs and suggest a universal unit (ARG copy per cell) for reporting such biological measurements of samples and improving the comparability of different surveillance efforts.

Для цитирования: Yin Xiaole, Chen Xi, Jiang Xiao-Tao, Yang Ying, Li Bing, Shum Marcus Ho-Hin, Lam Tommy T Y, Leung Gabriel M, Rose Joan, Sanchez-Cid Concepcion, Vogel Timothy M, Walsh Fiona, Berendonk Thomas U, Midega Janet, Uchea Chibuzor, Frigon Dominic, Wright Gerard D, Bezuidenhout Carlos, Picão Renata C, Ahammad Shaikh Z, Nielsen Per Halkjær, Hugenholtz Philip, Ashbolt Nicholas J, Corno Gianluca, Fatta-Kassinos Despo, Bürgmann Helmut, Schmitt Heike, Cha Chang-Jun, Pruden Amy, Smalla Kornelia, Cytryn Eddie, Zhang Yu, Yang Min, Zhu Yong-Guan, Dechesne Arnaud, Smets Barth F, Graham David W, Gillings Michael R, Gaze William H, Manaia Célia M, van Loosdrecht Mark C M, Alvarez Pedro J J, Blaser Martin J, Tiedje James M, Topp Edward, Zhang Tong. Toward a Universal Unit for Quantification of Antibiotic Resistance Genes in Environmental Samples.. Environmental science & technology. 2023. DOI: 10.1021/acs.est.3c00159.

Предметные рубрики MeSH

AnimalsHumansAnti-Bacterial AgentsRNA, Ribosomal, 16SDrug Resistance, MicrobialGenes, BacterialMetagenomics
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