Therapeutic advances in musculoskeletal disease · 2026
Frequency, diagnosis, and pharmacological treatment of giant cell arteritis in Germany: database analysis of medical insurance data.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Schmidt Wolfgang A, Alibone Marco, Ludwig Paul, Obermüller Dominik, Karl Franziska, Terner Stephanie, Venhoff Nils
Аннотация
BACKGROUND: For giant cell arteritis (GCA), a north-south gradient in incidence and prevalence has been described, peaking in Scandinavia.
OBJECTIVE: This analysis aimed to obtain up-to-date, representative data on the prevalence and incidence of GCA in Germany, updating the old, regional information on low incidence and prevalence rates.
DESIGN: Cross-sectional analysis using a large German health insurance database.
METHODS: This study is based on a cross-sectional analysis of claims data from the InGef (Institute for Health Research Berlin GmbH) research database, which includes a representative sample of 4.8 million insured individuals. Individuals aged ⩾50 years with continuous insurance coverage for a 3-year baseline period and the subsequent 2 years for longitudinal analysis were included. Estimates were standardised and projected to the German population.
RESULTS: Each year from 2018 to 2021, 1.7 million insured individuals met the inclusion and exclusion criteria. Extrapolated to the German population ⩾50 years in 2021, the incidence was 24/100,000, and the prevalence was 146/100,000. Diagnosis was made predominantly in outpatient settings by general practitioners (GP, 31.9%) and internists (19.5%), followed by rheumatologists (13.1%) and ophthalmologists (5.7%). Within 2 years, 16.3% of incident patients were referred to rheumatologists for treatment after diagnosis. Treatment was most commonly initiated by GPs (45.8%), followed by rheumatologists (36.1%), and included glucocorticoids (88.2%), methotrexate (26.7%), and tocilizumab (14.1%). Most common comorbidities of prevalent patients comprised arterial hypertension (77.2%), dyslipidaemia (55.0%), diabetes mellitus (28.8%), osteoporosis (34.6%), and cataract (31.2%).
CONCLUSION: Contrary to previous reports, Germany has higher incidence and prevalence rates of GCA than previously assumed. Only approximately one-third of the incident patients were initially treated by rheumatologists. Comorbidities such as diabetes or cardiovascular diseases were common.
OBJECTIVE: This analysis aimed to obtain up-to-date, representative data on the prevalence and incidence of GCA in Germany, updating the old, regional information on low incidence and prevalence rates.
DESIGN: Cross-sectional analysis using a large German health insurance database.
METHODS: This study is based on a cross-sectional analysis of claims data from the InGef (Institute for Health Research Berlin GmbH) research database, which includes a representative sample of 4.8 million insured individuals. Individuals aged ⩾50 years with continuous insurance coverage for a 3-year baseline period and the subsequent 2 years for longitudinal analysis were included. Estimates were standardised and projected to the German population.
RESULTS: Each year from 2018 to 2021, 1.7 million insured individuals met the inclusion and exclusion criteria. Extrapolated to the German population ⩾50 years in 2021, the incidence was 24/100,000, and the prevalence was 146/100,000. Diagnosis was made predominantly in outpatient settings by general practitioners (GP, 31.9%) and internists (19.5%), followed by rheumatologists (13.1%) and ophthalmologists (5.7%). Within 2 years, 16.3% of incident patients were referred to rheumatologists for treatment after diagnosis. Treatment was most commonly initiated by GPs (45.8%), followed by rheumatologists (36.1%), and included glucocorticoids (88.2%), methotrexate (26.7%), and tocilizumab (14.1%). Most common comorbidities of prevalent patients comprised arterial hypertension (77.2%), dyslipidaemia (55.0%), diabetes mellitus (28.8%), osteoporosis (34.6%), and cataract (31.2%).
CONCLUSION: Contrary to previous reports, Germany has higher incidence and prevalence rates of GCA than previously assumed. Only approximately one-third of the incident patients were initially treated by rheumatologists. Comorbidities such as diabetes or cardiovascular diseases were common.