Zeitschrift fur Rheumatologie · 2022
Colchicine linked with risk reduction for myocardial infarction in gout patients: systematic review and meta-analysis.
СтатьяМетаанализСистематический обзорНазвание и аннотация: Перевод в очереди
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Wan Huipeng, Zeng Linhong, Xiao Ruihai, Tang Xiaoyi, Shu Yan, Shen Shaochen
Аннотация
INTRODUCTION: This meta-analysis aimed to identify the effect of colchicine on myocardial infarction (MI) in patients with gout.
METHODS: In February 2021, a systematic computer-based search was conducted in PubMed, EMBASE, and Cochrane Database of Systematic Reviews. Data on patients with gout that compared colchicine versus others (no use of colchicine) were retrieved. The endpoints were the incidence rate for MI. After testing for heterogeneity between studies, data were aggregated for fixed-effects models when necessary.
RESULTS: Three clinical studies with 3012 patients (colchicine group = 1523, control group = 1489) were finally included in the meta-analysis. Colchicine was associated with a decreased risk for myocardial infarction (pooled odds ratio 0.35, 95% confidence interval 0.23-0.55, p < 0.00001).
CONCLUSIONS: Colchicine was effective in reducing the incidence of MI in patients with gout.
METHODS: In February 2021, a systematic computer-based search was conducted in PubMed, EMBASE, and Cochrane Database of Systematic Reviews. Data on patients with gout that compared colchicine versus others (no use of colchicine) were retrieved. The endpoints were the incidence rate for MI. After testing for heterogeneity between studies, data were aggregated for fixed-effects models when necessary.
RESULTS: Three clinical studies with 3012 patients (colchicine group = 1523, control group = 1489) were finally included in the meta-analysis. Colchicine was associated with a decreased risk for myocardial infarction (pooled odds ratio 0.35, 95% confidence interval 0.23-0.55, p < 0.00001).
CONCLUSIONS: Colchicine was effective in reducing the incidence of MI in patients with gout.