Epigenomics · 2021
DNA methylation as the link between migration and the major noncommunicable diseases: the RODAM study.
СтатьяМногоцентровое исследованиеResearch Support, N.I.H., IntramuralПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Chilunga Felix P, Henneman Peter, Venema Andrea, Meeks Karlijn Ac, Gonzalez Juan R, Ruiz-Arenas Carlos, Requena-Méndez Ana, Beune Erik, Spranger Joachim, Smeeth Liam, Bahendeka Silver, Owusu-Dabo Ellis, Klipstein-Grobusch Kerstin, Adeyemo Adebowale, Mannens Marcel Mam, Agyemang Charles
Аннотация
Aim: We assessed epigenome-wide DNA methylation (DNAm) differences between migrant and non-migrant Ghanaians. Materials & methods: We used the Illumina Infinium® HumanMethylation450 BeadChip to profile DNAm of 712 Ghanaians in whole blood. We used linear models to detect differentially methylated positions (DMPs) associated with migration. We performed multiple post hoc analyses to validate our findings. Results: We identified 13 DMPs associated with migration (delta-beta values: 0.2-4.5%). Seven DMPs in CPLX2, EIF4E3, MEF2D, TLX3, ST8SIA1, ANG and CHRM3 were independent of extrinsic genomic influences in public databases. Two DMPs in NLRC5 were associated with duration of stay in Europe among migrants. All DMPs were biologically linked to migration-related factors. Conclusion: Our findings provide the first insights into DNAm differences between migrants and non-migrants.