Head & neck · 2019
Adjuvant therapies in the management of medication-related osteonecrosis of the jaws: Systematic review.
СтатьяСистематический обзорНазвание и аннотация: Перевод в очереди
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de Souza Tolentino Elen, de Castro Tamara F, Michellon Felipe C, Passoni Ana C C, Ortega Lorena J A, Iwaki Lilian C V, da Silva Mariliani C
Аннотация
BACKGROUND: We investigated the efficacy of hyperbaric oxygen (HBO), low-intensity laser (LIL), and platelet-rich plasma (PRP) in the management of medication-related osteonecrosis of the jaws (MRONJ).
METHODS: A literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Two examiners independently assessed eligibility and risk of bias and extracted data.
RESULTS: There was improvement in 75.6% of the 41 patients submitted to HBO, with positive effects on pain relief and decreased size and number of lesions at a faster rate, with better effects when the drug was discontinued. For LIL, 158 (64.2%) of the 246 patients/sites improved the symptoms and 98 (39.8%) healed completely. Fourteen (17.3%) of the 81 patients treated with PRP significantly improved the symptoms and 65 (80.2%) completely healed.
CONCLUSIONS: These therapies served as safe and effective adjuvant modalities for MRONJ treatment. The lack of randomized clinical trials evidences the need for more high-quality investigations on the subject.
METHODS: A literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Two examiners independently assessed eligibility and risk of bias and extracted data.
RESULTS: There was improvement in 75.6% of the 41 patients submitted to HBO, with positive effects on pain relief and decreased size and number of lesions at a faster rate, with better effects when the drug was discontinued. For LIL, 158 (64.2%) of the 246 patients/sites improved the symptoms and 98 (39.8%) healed completely. Fourteen (17.3%) of the 81 patients treated with PRP significantly improved the symptoms and 65 (80.2%) completely healed.
CONCLUSIONS: These therapies served as safe and effective adjuvant modalities for MRONJ treatment. The lack of randomized clinical trials evidences the need for more high-quality investigations on the subject.
Предметные рубрики MeSH
AgedAged, 80 and overBisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsCombined Modality TherapyDenosumabDiphosphonatesFemaleHumansHyperbaric OxygenationJaw DiseasesLaser TherapyMaleMiddle AgedOsteonecrosisPain ManagementPamidronatePlatelet-Rich PlasmaRandomized Controlled Trials as Topic