Protective Effect of Jiawei Shuxin Tang on Myocardial Ischemia-Reperfusion in Rats with Qi Deficiency and Blood Stasis and Its Correlation with NRG-1.

OBJECTIVE

To investigate the protective effect of Jiawei Shuxin Tang (JWSXT) on myocardial ischemia-reperfusion injury (MIRI) rats with Qi deficiency and blood stasis and its correlation with neuregulin-1 (NRG-1).

METHODS

30 rats were used to establish the model of Qi deficiency and blood stasis, and were randomly divided into control group, MIRI model group, and JWSXT group. The traditional Chinese medicine (TCM) phenotypes, echocardiographic performance, myocardial reperfusion area, myocardial infarction area, HE staining, and NRG-1 content changes of rats in each group were compared one week after treatment.

RESULTS

We found that compared with the model group, rats in the JWSXT group showed increased activity as well as improved tongue texture and lip color (P<0.05); LVEF and LVFS increased in the JWSXT group (P<0.05; P<0.05). The percentage of infarct area and the percentage of myocardial ischemia reperfusion area in the JWSXT group was significantly reduced (P<0.05; P<0.05). Compared with the control group, the remaining NRG-1 content in myocardial tissues of rats in the two groups was decreased (P<0.01), and NRG-1 content in the JWSXT group was increased (P<0.05) compared with the model group.

CONCLUSIONS

JWSXT can improve reperfusion injury in rats with Qi deficiency and blood stasis infarction, which correlates with NRG-1.