Aspirin for Venous Thromboembolism Prophylaxis: Respecting the Patient Safety.

Aspirin is increasingly being used for venous thromboembolism (VTE) prophylaxis in patients undergoing total joint arthroplasty (TJA). It is considered a safer and more cost-effective alternative to other anticoagulants, with the added benefit of not requiring blood-level titration. Studies have shown that aspirin is effective in preventing VTE, with a lower risk of major bleeding and reduced mortality compared to other options. Additionally, aspirin provides indirect benefits such as a reduced risk of periprosthetic joint infections (PJIs), heterotopic ossification (HO), and joint stiffness, with no significant difference in aseptic loosening rates when compared to stronger anticoagulants.