[Experience of Performing Liver Biopsy in Combination with TAE for Recurrence of HR-Positive HER2-Negative Breast Cancer with Rapid Appearance of Organ Metastases].

The patient was a 54-year-old woman diagnosed with right breast cancer at the age of 49 with cT4bN1M0, cStage ⅢB, and underwent radical surgery after preoperative chemotherapy. The histopathologic diagnosis was invasive ductal carcinoma, histological treatment effect Grade 1a, HR positive HER2 negative, chest wall irradiation and hormone therapy as postoperative treatment. At 5 years after surgery, there were no signs of recurrence on the imaging, but at a routine checkup 4 months later, left back pain and hip joint pain were observed, and bone metastases were diagnosed by MRI. PET- CT revealed multiple liver, lung, bone and lymph node metastases, and the course of recurrence was rapid in a short period of time. To re-evaluate the subtype, a liver biopsy was performed in combination with TAE to prevent bleeding for liver tumors with abundant blood flow. As a result, PgR turned negative, but there was no change in subtype. After irradiation to the pain area, paclitaxel and bevacizumab therapy was administered, and a marked reduction of pulmonary and liver metastases, and the disappearance of pain were observed. Local hepatic therapy with TAE followed by chemotherapy was thought to have helped the patient overcome the rapid tumor growth.