Стратегии изменения болезней: выявление белковых киназ в множественных склерозах и других аутоиммунных расстройствах.
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Konen Franz Felix, Möhn Nora, Witte Torsten, Schefzyk Matthias, Wiestler Miriam, Lovric Svjetlana, Hufendiek Karsten, Jendretzky Konstantin Fritz, Gingele Stefan, Schwenkenbecher Philipp, Sühs Kurt-Wolfram, Friese Manuel A, Klotz Luisa, Pul Refik, Pawlitzki Marc, Hagin David, Kleinschnitz Christoph, Meuth Sven G, Skripuletz Thomas
Аннотация
Оригинал публикации
Disease-modifying strategies: Targeting protein kinases in multiple sclerosis and other autoimmune disorders.
A wide variety of immunomodulatory therapies are already available for the treatment of multiple sclerosis (MS). Through fundamental insights from basic research with a gain of knowledge in the pathological processes underlying MS, the exploration of additional medical compounds within clinical trials has been ignited. Emerging novel medications with innovative mechanisms of action are being introduced. Those mechanisms of action include a broad therapeutic spectrum of substances targeting various protein kinases, some of which could also be used for the treatment of other autoimmune-mediated diseases. The advancement of new compounds could therefore enable a more personalized approach in treating MS, taking into consideration patients' co-existing autoimmune-mediated diseases. In this review, we discuss potential compounds targeting protein kinases, currently under investigation in clinical trials for various autoimmune diseases that could become viable treatment options for MS and comorbid autoimmune conditions in the future.