Spine · 2025
Prevalence of Neural Axis Abnormalities in Typical and Atypical Laterality Idiopathic Scoliosis: A Systematic Review and Meta-Analysis of Observational Studies.
СтатьяСистематический обзорМетаанализНазвание и аннотация: Перевод в очереди
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Cortés-Pérez Irene, Gallego-Siles Juan R, Obrero-Gaitán Esteban, Ibáñez-Vera Alfonso J, Peinado-Rubia Ana B, Lomas-Vega Rafael
Аннотация
STUDY DESIGN: Systematic review and meta-analysis of observational studies.
OBJECTIVE: This systematic review and meta-analysis aimed to assess the possible relationship between atypical laterality curves and neural axis abnormalities (NAAs).
SUMMARY: Idiopathic scoliosis (IS) is a three-dimensional spinal deformity of unknown origin. Some studies have shown a high prevalence of (NAAs) in patients with IS, with possible differences in the prevalence of NAAs between curves with typical (right thoracic/left lumbar) or atypical laterality (the rest).
METHODS: This review protocol was previously registered in PROSPERO (CRD42024544809). A systematic search of the PubMed, Scopus, Web of Science, CINAHL and Scopus databases was performed through September 30, 2024.
RESULTS: A total of 24 articles published between 1992 and 2021 involving 5379 subjects were included in the analysis. Twenty-four studies reported a prevalence of NAAs among patients with atypical laterality curves of 19.4% (95% CI: 15.6-23.8) and 12.1% (95% CI: 0.1-0.16) among those with typical laterality curves. Eleven studies estimated the prevalence of syringomyelia in patients with atypical laterality at 12.4% (95% CI: 8-18.7) and that in patients with typical laterality at 6.1% (95% CI: 3.8-9.5). Eleven studies reported a prevalence of Arnold-Chiari syndrome in patients with atypical laterality of 12% (95% CI: 6.9-20.1) and 7.7% (95% CI: 3.7-15.4) in those with typical laterality curves. Five studies reported a prevalence of tethered cord at 3.1% (95% CI: 1.3-7.2-) in patients with atypical laterality curves and a 2.1% (95% CI: 0.5-8.8-) prevalence among those with typical laterality.
CONCLUSION: This study revealed that the prevalence of associated NAAs is greater among IS patients with atypical laterality curves, especially in patients with left dorsal curves and/or right lumbar curves. Syringomyelia is the most significant associated anomaly.
OBJECTIVE: This systematic review and meta-analysis aimed to assess the possible relationship between atypical laterality curves and neural axis abnormalities (NAAs).
SUMMARY: Idiopathic scoliosis (IS) is a three-dimensional spinal deformity of unknown origin. Some studies have shown a high prevalence of (NAAs) in patients with IS, with possible differences in the prevalence of NAAs between curves with typical (right thoracic/left lumbar) or atypical laterality (the rest).
METHODS: This review protocol was previously registered in PROSPERO (CRD42024544809). A systematic search of the PubMed, Scopus, Web of Science, CINAHL and Scopus databases was performed through September 30, 2024.
RESULTS: A total of 24 articles published between 1992 and 2021 involving 5379 subjects were included in the analysis. Twenty-four studies reported a prevalence of NAAs among patients with atypical laterality curves of 19.4% (95% CI: 15.6-23.8) and 12.1% (95% CI: 0.1-0.16) among those with typical laterality curves. Eleven studies estimated the prevalence of syringomyelia in patients with atypical laterality at 12.4% (95% CI: 8-18.7) and that in patients with typical laterality at 6.1% (95% CI: 3.8-9.5). Eleven studies reported a prevalence of Arnold-Chiari syndrome in patients with atypical laterality of 12% (95% CI: 6.9-20.1) and 7.7% (95% CI: 3.7-15.4) in those with typical laterality curves. Five studies reported a prevalence of tethered cord at 3.1% (95% CI: 1.3-7.2-) in patients with atypical laterality curves and a 2.1% (95% CI: 0.5-8.8-) prevalence among those with typical laterality.
CONCLUSION: This study revealed that the prevalence of associated NAAs is greater among IS patients with atypical laterality curves, especially in patients with left dorsal curves and/or right lumbar curves. Syringomyelia is the most significant associated anomaly.