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Войти в исследования Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion · 2022
Inflammasome genes polymorphisms and susceptibility to gout. Is there a link?
СтатьяНазвание и аннотация: Перевод в очереди
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Clavijo-Cornejo Denise, López-Reyes Alberto, Cruz-Arenas Esteban, Jacobo-Albavera Leonor, Rivera-Tlaltzicapa Daniel, Francisco-Balderas Adriana, Domínguez-Pérez Mayra, Romero-Morelos Pablo, Vázquez-Mellado Janitzia, Silveira Luis H, Pineda Carlos, Martínez-Nava Gabriela, Gutierrez Marwin
Аннотация
BACKGROUND: The inflammatory response in gout disease is induced by the activation of NLR family pyrin domain-containing 3 (NLPR3) signaling pathway mediated by IL-1β release.
OBJECTIVE: The objective of the study was to determine the association between single nucleotide polymorphisms (SNPs) within NLRP3 inflammasome genes and gout susceptibility.
METHODS: Mexican patients with gout from the National Rehabilitation Institute and General Hospital of Mexico were enrolled. A healthy control group was also included. We analyzed the frequency and allelic distribution of eight SNPs from seven different genes within the NLRP3 inflammasome signaling pathway: TLR4 rs2149356, CD14 rs2569190, NLRP3 rs3806268, NLRP3 rs10754558, CARD8 rs2043211, IL-1β rs1143623, P2RX7 rs3751142, and PPARGC1B rs45520937 SNPs.
RESULTS: We found that the SNP rs45520937 of PPARGC1B was associated with the risk of developing gout when it was analyzed using the dominant model (Odds ratio [OR] = 2.30; 95% confidence interval [CI]: 1.09-4.86; p = 0.030), and it is proposed that the adaptor molecule CD14 rs2569190 polymorphism could be associated with a lower risk of gout under an additive model (OR= 0.41;95% CI: 0.16-1.05; p = 0.064). No significant associations were identified for the remaining SNPs.
CONCLUSION: Our findings suggest that the PPARGC1B rs45520937 SNP is associated with gout susceptibility.
OBJECTIVE: The objective of the study was to determine the association between single nucleotide polymorphisms (SNPs) within NLRP3 inflammasome genes and gout susceptibility.
METHODS: Mexican patients with gout from the National Rehabilitation Institute and General Hospital of Mexico were enrolled. A healthy control group was also included. We analyzed the frequency and allelic distribution of eight SNPs from seven different genes within the NLRP3 inflammasome signaling pathway: TLR4 rs2149356, CD14 rs2569190, NLRP3 rs3806268, NLRP3 rs10754558, CARD8 rs2043211, IL-1β rs1143623, P2RX7 rs3751142, and PPARGC1B rs45520937 SNPs.
RESULTS: We found that the SNP rs45520937 of PPARGC1B was associated with the risk of developing gout when it was analyzed using the dominant model (Odds ratio [OR] = 2.30; 95% confidence interval [CI]: 1.09-4.86; p = 0.030), and it is proposed that the adaptor molecule CD14 rs2569190 polymorphism could be associated with a lower risk of gout under an additive model (OR= 0.41;95% CI: 0.16-1.05; p = 0.064). No significant associations were identified for the remaining SNPs.
CONCLUSION: Our findings suggest that the PPARGC1B rs45520937 SNP is associated with gout susceptibility.