[Late sequelae after treatment of sarcomas and solitary metastases in the musculoskeletal system].

This review addresses the treatment of malignant musculoskeletal tumours associated with significant late effects. Surgical resection and reconstruction may result in chronic pain, reduced muscle strength, limited joint mobility, mechanical failure of implants, and need for reoperation. Radiotherapy increases the risk of wound complications, fibrosis, fractures, and secondary malignancies, while chemotherapy may cause cardiac, renal, and skeletal toxicity. Amputation and limb-sparing procedures alike are linked to functional and psychosocial consequences, including anxiety, depression, and altered body image.