Scientific reports · 2023
YKL-40 serum levels are predicted by inflammatory state, age and diagnosis of idiopathic inflammatory myopathies.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Vázquez-Del Mercado Mónica, Pérez-Vázquez Felipe, Márquez-Aguirre Ana L, Martínez-García Erika-Aurora, Chavarria-Avila Efrain, Ramos-Becerra Carlos G, Aguilar-Vázquez Andrea, Godínez-Rubí Marisol, Martín-Márquez Beatriz-Teresita, Gómez-Limón Livier, Márquez-De-La-Paz Guillermo, Rubio-Arellano Edy-David, Pizano-Martinez Oscar
Аннотация
YKL-40 increase according to the aging process, and its functions have been associated with tissue remodeling and systemic inflammation. In Rheumatoid Arthritis (RA) it has been proposed as a possible biomarker of activity and severity, however; in the field of idiopathic inflammatory myopathies (IIM) the role of YKL-40 in IIM is not clear. Thus, we aimed to evaluate if there is an association between the serum levels and muscle tissue expression of YKL-40 with age, IIM phenotype, muscle strength and myositis disease activity. The main finding was that age is the most important variable that affects the YKL-40 serum levels. In muscle biopsy, we observed that YKL-40 is mainly expressed in infiltrating lymphoid cells than in muscle tissue. Using ANCOVA according to the b-coefficients, YKL-40 serum levels are predicted by inflammatory state, age, and IIM diagnosis.