Translational cancer research · 2026
Radiation biomarkers in body fluids: translational perspectives for precision radiotherapy-a narrative review.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Monzen Satoru, Kotani Akihito, Muro Atsushi, Zuo Boyang, Fukushi Yasuyo, Sakamoto Riki, Wojcik Andrzej, Mariya Yasushi
Аннотация
BACKGROUND AND OBJECTIVE: Radiotherapy and radionuclide therapy are essential components of modern cancer treatment. Despite substantial advances in radiation delivery and treatment planning, considerable interindividual variability remains in therapeutic response and radiation-induced toxicity. Conventional monitoring approaches, including imaging and routine laboratory tests, often provide limited insight into early or systemic biological responses. Body fluid-based biomarkers may provide accessible molecular readouts of radiation-induced damage, host response, and treatment-related toxicity. This narrative review summarizes radiation biomarkers detectable in body fluids, with emphasis on oxidative stress and cellular damage markers, circulating RNAs and extracellular vesicles, and metabolomic and lipidomic signatures relevant to precision radiation medicine.
METHODS: A targeted literature search was conducted using PubMed/MEDLINE and Web of Science. Priority was given to primary experimental and clinical studies reporting specific molecular findings, longitudinal biomarker changes, or associations with treatment response and radiation-induced toxicity.
KEY CONTENT AND FINDINGS: Ionizing radiation induces oxidative stress, DNA damage, inflammatory signaling, metabolic reprogramming, and intercellular communication, generating measurable signals in blood, plasma, serum, and urine. Oxidative DNA damage products such as 8-hydroxy-2'-deoxyguanosine and γ-H2AX-related responses may reflect cellular injury and toxicity risk. Circulating microRNAs and extracellular vesicle-associated cargo may capture transcriptional responses, bystander signaling, and treatment-related systemic changes. Metabolomic and lipidomic studies have identified multimetabolite signatures associated with radiation exposure and normal tissue toxicity. However, most candidate biomarkers remain exploratory, and clinical implementation is limited by variability in sampling, analytical platforms, normalization, and external validation.
CONCLUSIONS: Integrated longitudinal assessment of complementary biomarker classes, together with clinical and dosimetric information, may improve toxicity monitoring and treatment personalization. Prospective validation and methodological standardization are required before these biomarkers can support routine treatment adaptation.
METHODS: A targeted literature search was conducted using PubMed/MEDLINE and Web of Science. Priority was given to primary experimental and clinical studies reporting specific molecular findings, longitudinal biomarker changes, or associations with treatment response and radiation-induced toxicity.
KEY CONTENT AND FINDINGS: Ionizing radiation induces oxidative stress, DNA damage, inflammatory signaling, metabolic reprogramming, and intercellular communication, generating measurable signals in blood, plasma, serum, and urine. Oxidative DNA damage products such as 8-hydroxy-2'-deoxyguanosine and γ-H2AX-related responses may reflect cellular injury and toxicity risk. Circulating microRNAs and extracellular vesicle-associated cargo may capture transcriptional responses, bystander signaling, and treatment-related systemic changes. Metabolomic and lipidomic studies have identified multimetabolite signatures associated with radiation exposure and normal tissue toxicity. However, most candidate biomarkers remain exploratory, and clinical implementation is limited by variability in sampling, analytical platforms, normalization, and external validation.
CONCLUSIONS: Integrated longitudinal assessment of complementary biomarker classes, together with clinical and dosimetric information, may improve toxicity monitoring and treatment personalization. Prospective validation and methodological standardization are required before these biomarkers can support routine treatment adaptation.