Archives of dermatology · 2007
Angiogenesis in cutaneous lesions of leprosy: implications for treatment.
СтатьяПоддержка NIH: внешняя программаПоддержка правительства СШАНазвание и аннотация: Перевод в очереди
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Bhandarkar Sulochana S, Cohen Cynthia, Kuruvila Maria, Rea Thomas H, Mackelfresh Jamie B, Lee Delphine J, Modlin Robert L, Arbiser Jack L
Аннотация
OBJECTIVE: To examine the potential role of angiogenesis in leprosy.
DESIGN: Immunohistochemical analysis of leprosy lesions.
SETTING: Department of Dermatology, Venereology, and Leprology, Kasturba Medical College; Division of Dermatology, University of California at Los Angeles; and Departments of Dermatology and Pathology, Emory University.
PATIENTS: Thirty-two cutaneous lesions that represented the spectrum of leprosy were obtained from 32 patients.
MAIN OUTCOME MEASURE: CD31 microvessel counts.
RESULTS: The mean CD31 microvessel count in borderline tuberculoid, midborderline, and lepromatous leprosy lesions was significantly higher than in indeterminate leprosy lesions.
CONCLUSIONS: Increased bacterial load is associated with increased angiogenesis. Angiogenesis inhibitors may be of benefit in the treatment of leprosy.
DESIGN: Immunohistochemical analysis of leprosy lesions.
SETTING: Department of Dermatology, Venereology, and Leprology, Kasturba Medical College; Division of Dermatology, University of California at Los Angeles; and Departments of Dermatology and Pathology, Emory University.
PATIENTS: Thirty-two cutaneous lesions that represented the spectrum of leprosy were obtained from 32 patients.
MAIN OUTCOME MEASURE: CD31 microvessel counts.
RESULTS: The mean CD31 microvessel count in borderline tuberculoid, midborderline, and lepromatous leprosy lesions was significantly higher than in indeterminate leprosy lesions.
CONCLUSIONS: Increased bacterial load is associated with increased angiogenesis. Angiogenesis inhibitors may be of benefit in the treatment of leprosy.