International journal of dermatology · 2006
Histopathological study of apparently normal skin of patients with leprosy.
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El-Darouti Mohammad A, Hussein Soliman, Marzouk Salonaz A, Nabil Naglaa, Hunter Nahla S, Mahgoub Duaa, El-Eishi Nermine H, Abdel-Halim Mona R E
Аннотация
BACKGROUND: Several clinical and laboratory observations point to the possible microscopical affection of normal-looking skin in leprosy.
OBJECTIVE: This study was carried out to verify the microscopical affection of apparently normal-looking skin in different types of leprosy.
PATIENTS AND METHODS: The study included 50 patients with different clinical types of leprosy. Biopsies from both skin lesions and normal-looking skin were obtained from each patient and examined for microscopical evidence of leprosy.
RESULTS: Microscopical affection of normal-looking skin was detected in 52% of our cases, with higher incidence of affection towards the lepromatous end of the disease.
CONCLUSION: Our findings underscore that the incidence of microscopical affection of normal-looking skin in leprosy is much higher on the lepromatous end of the spectrum of leprosy than on the tuberculoid end; during treatment, the leprosy granulomas may disappear from the normal skin before the clinical lesions. Moreover, the microscopic picture of indeterminate leprosy can be observed in the normal-looking skin of patients with tuberculoid leprosy or lepromatous leprosy, and this description appears not to be confined to the entity known as indeterminate leprosy.
OBJECTIVE: This study was carried out to verify the microscopical affection of apparently normal-looking skin in different types of leprosy.
PATIENTS AND METHODS: The study included 50 patients with different clinical types of leprosy. Biopsies from both skin lesions and normal-looking skin were obtained from each patient and examined for microscopical evidence of leprosy.
RESULTS: Microscopical affection of normal-looking skin was detected in 52% of our cases, with higher incidence of affection towards the lepromatous end of the disease.
CONCLUSION: Our findings underscore that the incidence of microscopical affection of normal-looking skin in leprosy is much higher on the lepromatous end of the spectrum of leprosy than on the tuberculoid end; during treatment, the leprosy granulomas may disappear from the normal skin before the clinical lesions. Moreover, the microscopic picture of indeterminate leprosy can be observed in the normal-looking skin of patients with tuberculoid leprosy or lepromatous leprosy, and this description appears not to be confined to the entity known as indeterminate leprosy.