Right Heart Catheterization in Patients With Advanced Heart Failure: Novel Hemodynamic Parameters for Risk Stratification.

PURPOSE: The aim of this exploratory randomized controlled clinical trial was to compare profilometric and radiographic changes following early implant placement in sites treated with alveolar ridge preservation versus spontaneous healing (SH). Additionally, the study aimed to investigate clinical parameters of the implants up to 3 years following crown insertion.

METHODS

Thirty-five patients exhibiting either intact buccal bone plates or buccal dehiscence of up to 50% after single-tooth extraction of incisors, canines, or premolars were enrolled. Participants were randomly assigned to 1 of 3 groups: 1) deproteinized bovine bone mineral with 10% collagen covered by a collagen matrix (DBBM-C/CM), 2) deproteinized bovine bone mineral with 10% collagen alone (DBBM-C), or 3) SH. Implant placement occurred 8 weeks post-extraction. Profilometric analyses were performed utilizing impressions and digital scans. Patients underwent follow-up assessments for up to 3 years (FU-3Y) after the final crown insertion (fixed dental prosthesis insertion, FDPi).

RESULTS

The median contour changes between FDPi and FU-3Y were -0.23 mm for DBBM-C/CM, -0.21 mm for DBBM-C, and -0.33 mm for SH, demonstrating a statistically significant reduction over 3 years in all 3 groups (P<0.05). Median radiographic changes observed up to FU-3Y were 0.02 mm for DBBM-C/CM, -0.5 mm for DBBM-C, and -0.18 mm for SH. These radiographic changes were neither statistically significant within groups nor between groups over time (P>0.05). Clinical parameters remained stable throughout the study period in all groups.

CONCLUSIONS

The FU-3Y of this randomized clinical trial revealed stable clinical parameters and marginal bone levels in all evaluated groups. Although minor contour reductions were noted in all groups, these changes were deemed clinically acceptable.

TRIAL REGISTRATION: German Clinical Trials Register Identifier: DRKS00009496.