Медицинская библиотека · International journal of cardiology · 2018

Serum lipoprotein(a) is not modified by interleukin-6 receptor antagonism or associated with inflammation in non-ST-elevation myocardial infarction.

Ueland Thor, Kleveland Ola, Michelsen Annika E, Wiseth Rune, Damås Jan Kristian, Holven Kirsten B, Aukrust Pål, Gullestad Lars, Yndestad Arne, Halvorsen Bente

СтатьяРандомизированное исследованиеПеревод в очереди

Аннотация

BACKGROUND

The IL-6 receptor antagonist tocilizumab has been shown to attenuate the proatherogenic lipoprotein a [Lp(a)] in rheumatoid arthritis. We evaluated if a single dose of tocilizumab reduced Lp(a) in patients with non-ST-elevation myocardial infarction (NSTEMI).

METHODS

Lp(a) was assessed by immunoassay (n = 117 patients) at 7 consecutive time-points between day 1 and 3 and at 3 and 6 months follow-up.

RESULTS

Tocilizumab did not affect Lp(a) at any time-point during the study and was not associated with cardiovascular risk factors.

CONCLUSIONS

Short-time inhibition of IL-6 with tocilizumab in patients with NSTEMI did not influence Lp(a) levels.

Для цитирования: Ueland Thor, Kleveland Ola, Michelsen Annika E, Wiseth Rune, Damås Jan Kristian, Holven Kirsten B, Aukrust Pål, Gullestad Lars, Yndestad Arne, Halvorsen Bente. Serum lipoprotein(a) is not modified by interleukin-6 receptor antagonism or associated with inflammation in non-ST-elevation myocardial infarction.. International journal of cardiology. 2018. DOI: 10.1016/j.ijcard.2018.06.093.

Предметные рубрики MeSH

Antibodies, Monoclonal, Humanized Biomarkers Dose-Response Relationship, Drug Double-Blind Method Electrocardiography Female Follow-Up Studies Humans Immunoassay Inflammation Lipoprotein(a)Male Middle Aged Non-ST Elevated Myocardial Infarction Receptors, Interleukin-6 Treatment Outcome

Подготовка и перевод публикации

Обработка статьи · этапы, ошибки и управление

Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.