The role played by neural crest cells in the development of syndrome X: a hypothesis.

This study evaluated the components and the related hormone releasing organs, the mechanism of action of these hormones, and the origins of the cells and organs in a disorder known as metabolic syndrome X, the prevalence of which is rapidly increasing particularly among the adult population of industrial societies. Metabolic syndrome X, involving carbohydrate and lipid metabolism disorders and cardiovascular disorders caused by the release of primary hormones, alpha and beta cells of the islets of Langerhans of pancreas, adrenal gland medulla's chromaffin cells, sympathetic nervous system neurons and ganglia, adenohypophysis, neurohypophysis and hypothalamus, were evaluated for being neuroectodermal and mainly having neural crest origin. Generally the cells, tissues and organs involved are neuroectodermal and especially have neural crest origins; and to conclude, in prevention, diagnosis and treatment of this disorder the priority is the analysis and understanding of the migration, differentiation and adaptation at the target of neural crest cells.