Positive correlation between IL-6 levels and lumbar bone mineral density in menopausal women diagnosed with osteoporosis in comparison to menopausal women without osteoporosis.

BACKGROUND

Osteoporosis is a common bone disorder characterized by decreased bone density. Interleukin-6 (IL-6), plays a crucial role in bone homeostasis. This study aimed to evaluate the relationship between serum levels of IL-6 and lumbar bone marrow density (LBMD) in postmenopausal women with osteoporosis compared to those without the condition. In addition we investigated the level of PTH, ALP, Ca, FSH and LH in case and control and compared them between two groups. MATERIALS AND

METHODS

In this study, 5cc of blood was collected from 60 participants (case and control) without anticoagulant. Serum was separated and stored at -20 °C. ALP and calcium (Ca) were measured using a colorimetric method, while PTH, LH, and FSH levels were assessed by enzyme-linked immunosorbent assay (ELISA). The results were analyzed by SPSS version 18, with a significance level set at p < 0.05.

RESULTS

Our findings showed the serum level of IL-6 increased significantly in postmenopausal women with osteoporosis compared to the control group (p-value = 0.001). Serum levels of LH, FSH, ALP, and PTH in both groups were not statistically different (p-value = 0.089). Additionally, we found a positive correlation between BMD Lumbar with IL-6 in menopausal women with osteoporosis.

CONCLUSION

Our findings illustrated the positive correlation between lumbar spine BMD with IL-6, FSH, ALP, and Ca in MPO women, while hip BMD positively correlated with IL-6, PTH, and FSH serum levels. The correlations between various factors were not statistically significant, except for the relationship between BMD in the lumbar spine and IL-6 levels.