[Nature of physico-chemical changes in the membranes and chromatin of the lymphocyte nuclei in patients with rheumatoid arthritis].

Functional activity of lymphocytes, revealed by means of fluorometric study of the physicochemical properties of the membranes (according to the degree of binding with MBD) and nuclei (according to the degree of AO adsorption on chromatin DNA) was different in patients suffering from rheumatoid arthritis with different blood titers of RF determined by Vaaler-Rose's test. The lowered lymphocyte count in blood plasma was coupled with high functional activity of genome in patients with seronegative RA and with low in seropositive RA patients. Changes in the fluorescence of MBD bound with the membrane differed from those in the fluorescence of AO bound with lymphocyte chromatin. The DNA level in blood plasma of patients with seropositive RA was higher as compared with its levels seen in seronegative patients and healthy subjects.