[Hypophosphoremic osteomalacia secondary to benign connective tissue tumors: a report on three unusual cases with vitamin D metabolites measurements (author's transl)].

Three cases of benign connective tissue tumors (intracranial frontal hemangiopericytoma, rectosigmoid hemangioma, intraspinal neurinoma) associated with hypophosphoremic osteomalacia and reduction in plasma 1-25 (OH)2D levels are described. Rapid reversal of biological anomalies and subsequent recovery from clinical manifestations were observed after tumor ablation. Twenty-two identical cases have been reported in the published literature. The sharp- fall in 1-25 (OH)2D levels without secondary hypocalcemia or hyperparathyroidism suggests that intestinal absorption of calcium is not entirely dependent on this metabolite. Increased phosphoremia without a parallel rise in 1-25 (OH)2D levels was noted in one case. The possibility of an existing connective tissue tumor should be explored in all cases of hypophosphoremic osteomalacia.