Internal medicine (Tokyo, Japan) · 2022
Dermatomyositis Which Was Double Positive for Anti-MDA5 and Anti-ARS Antibodies That Was Successfully Treated by Intensive Immunosuppressive Therapy.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Hama Satoshi, Higashida-Konishi Misako, Akiyama Mitsuhiro, Shimada Tatsuya, Takei Hiroshi, Izumi Keisuke, Oshima Hisaji, Okano Yutaka
Аннотация
Myositis-specific autoantibody is associated with the clinical phenotype and prognosis of dermatomyositis. Anti-melanoma differentiation-associated gene 5 (MDA5) and anti-aminoacyl-tRNA synthetase (ARS) antibodies are generally mutually exclusive. We herein present an extremely rare case of dermatomyositis which showed double positivity for anti-MDA5 and anti-ARS antibodies. There have been very few reported cases of double positive anti-MDA5, anti-ARS antibodies. In such cases, the clinical characteristics of each autoantibody can coexist. Thus, we should pay attention to the rapidly progressing features of anti-MDA5 as well as the chronic relapsing features of anti-ARS for the better management of this rare condition.