MedElevator Войти в исследования
← Поиск публикаций

DOI 10.1038/s41598-017-14778-y

Медицинская библиотека · Scientific reports · 2017

Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head.

Sakamoto Yuma, Yamamoto Takuaki, Sugano Nobuhiko, Takahashi Daisuke, Watanabe Toshiyuki, Atsumi Takashi, Nakamura Junichi, Hasegawa Yukiharu, Akashi Koichi, Narita Ichiei, Miyamoto Takeshi, Takeuchi Tsutomu, Ikari Katsunori, Amano Koichi, Fujie Atsuhiro, Kubo Toshikazu, Tada Yoshifumi, Kaneuji Ayumi, Nakamura Hiroaki, Miyamura Tomoya, Kabata Tamon, Yamaji Ken, Okawa Takahiro, Sudo Akihiro, Ohzono Kenji, Tanaka Yoshiya, Yasunaga Yuji, Matsuda Shuichi, Imai Yuuki, Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral Head, Akiyama Masato, Kubo Michiaki, Kamatani Yoichiro, Iwamoto Yukihide, Ikegawa Shiro

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

Idiopathic osteonecrosis of the femoral head (IONFH) is an ischemic disorder that causes bone necrosis of the femoral head, resulting in hip joint dysfunction. IONFH is a polygenic disease and steroid and alcohol have already known to increase its risk; however, the mechanism of IONFH remains to be elucidated. We performed a genome-wide association study using ~60,000 subjects and found two novel loci on chromosome 20q12 and 12q24. Big data analyses identified LINC01370 as a candidate susceptibility gene in the 20q12 locus. Stratified analysis by IONFH risk factors suggested that the 12q24 locus was associated with IONFH through drinking capacity. Our findings would shed new light on pathophysiology of IONFH.

Для цитирования: Sakamoto Yuma, Yamamoto Takuaki, Sugano Nobuhiko, Takahashi Daisuke, Watanabe Toshiyuki, Atsumi Takashi, Nakamura Junichi, Hasegawa Yukiharu, Akashi Koichi, Narita Ichiei, Miyamoto Takeshi, Takeuchi Tsutomu, Ikari Katsunori, Amano Koichi, Fujie Atsuhiro, Kubo Toshikazu, Tada Yoshifumi, Kaneuji Ayumi, Nakamura Hiroaki, Miyamura Tomoya, Kabata Tamon, Yamaji Ken, Okawa Takahiro, Sudo Akihiro, Ohzono Kenji, Tanaka Yoshiya, Yasunaga Yuji, Matsuda Shuichi, Imai Yuuki, Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral Head, Akiyama Masato, Kubo Michiaki, Kamatani Yoichiro, Iwamoto Yukihide, Ikegawa Shiro. Genome-wide Association Study of Idiopathic Osteonecrosis of the Femoral Head.. Scientific reports. 2017. DOI: 10.1038/s41598-017-14778-y.

Предметные рубрики MeSH

Alcohol DrinkingChromosomes, Human, Pair 12Chromosomes, Human, Pair 20FemaleFemur HeadFemur Head NecrosisGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMultifactorial InheritanceOsteoarthritis, HipPolymorphism, Single Nucleotide
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.