International journal of clinical and experimental pathology · 2017
BPA exposure is related to metabolic changes in obese Saudi children.
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Al-Daghri Nasser M, Abd-Alrahman Sherif H, Bukhari Ihtisham, Panigrahy Amaresh, Khattak Malak Nk, Alokail Majed
Аннотация
BACKGROUND AND OBJECTIVE: Bisphenol A (BPA) disturbs the metabolism in animals and humans through effecting endocrine system. The role of BPA in obesity is not studied well. Therefore, current study is conducted to investigate its association with childhood obesity.
METHODS: Using gas chromatography-mass spectrometry (GC-MS/MS) serum BPA level was measured in 177 (120 normal and 57 obese) Saudi children.
RESULTS: The analyses of the data revealed an elevated level of serum BPA, leptin, systolic blood pressure, triglyceride, insulin and vitamin D in obese children as compare to normal controls. An elevated serum BPA did not show association with increased vitamin D and insulin while positively associated with some of the key markers of obesity. BPA was also positively associated with laptin, insulin and diastolic blood pressure in individuals of both normal and obese groups but with little statistical differences.
CONCLUSION: Higher BPA level in obese children reveals that it may involve in the childhood obesity as it has shown a significant association with the key makers of the obesity in obese children especially in boys.
METHODS: Using gas chromatography-mass spectrometry (GC-MS/MS) serum BPA level was measured in 177 (120 normal and 57 obese) Saudi children.
RESULTS: The analyses of the data revealed an elevated level of serum BPA, leptin, systolic blood pressure, triglyceride, insulin and vitamin D in obese children as compare to normal controls. An elevated serum BPA did not show association with increased vitamin D and insulin while positively associated with some of the key markers of obesity. BPA was also positively associated with laptin, insulin and diastolic blood pressure in individuals of both normal and obese groups but with little statistical differences.
CONCLUSION: Higher BPA level in obese children reveals that it may involve in the childhood obesity as it has shown a significant association with the key makers of the obesity in obese children especially in boys.