Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors: Data from the EuroSpA collaboration.
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Ørnbjerg Lykke M, Linde Louise, Georgiadis Stylianos, Rasmussen Simon H, Lindström Ulf, Askling Johan, Michelsen Brigitte, Giuseppe Daniela Di, Wallman Johan K, Pavelka Karel, Závada Jakub, Nissen Michael J, Jones Gareth T, Relas Heikki, Pirilä Laura, Tomšič Matija, Rotar Ziga, Geirsson Arni Jon, Gudbjornsson Bjorn, Kristianslund Eirik K, van Sder Horst-Bruinsma Irene, Loft Anne Gitte, Laas Karin, Iannone Florenzo, Corrado Addolorata, Ciurea Adrian, Santos Maria J, Santos Helena, Codreanu Catalin, Akkoc Nurullah, Gunduz Ozgul S, Glintborg Bente, Østergaard Mikkel, Hetland Merete Lund
Аннотация
METHODS: Baseline demographic and clinical characteristics were collected. Outcomes were investigated per registry and in pooled data using logistic regression analyses on multiply imputed data.
RESULTS: The consistency of baseline predictors in individual registries justified pooling the data. In the pooled dataset (n = 21,196), the 6-month rates for ASDAS inactive disease and ASDAS CII were 26% and 51%, and the 12-month drug retention rate 65% in patients with available data (n = 9,845, n = 6,948 and n = 21,196, respectively). Nine common baseline predictors of ASDAS inactive disease, ASDAS CII and 12-month drug retention were identified, and the odds ratios (95%-confidence interval) for ASDAS inactive disease were: age, per year: 0.97 (0.97-0.98), men vs. women: 1.88 (1.60-2.22), current vs. non-smoking: 0.76 (0.63-0.91), HLA-B27 positive vs. negative: 1.51 (1.20-1.91), TNF start year 2015-2018 vs. 2009-2014: 1.24 (1.06-1.45), CRP>10 vs. ≤10 mg/l: 1.49 (1.25-1.77), one unit increase in health assessment questionnaire (HAQ): 0.77 (0.58-1.03), one-millimeter (mm) increase in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) fatigue and spinal pain: 0.99 (0.99-1.00) and 0.99 (0.99-1.99), respectively CONCLUSION: Common baseline predictors of treatment response and adherence to TNFi could be identified across data from 15 European registries, indicating that they may be universal across different axSpA populations.