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DOI 10.4155/fsoa-2018-0101

Медицинская библиотека · Future science OA · 2019

Medication persistence for psoriatic arthritis in a Brazilian real-world setting.

Ribeiro da Silva Michael Ruberson, Ribeiro Dos Santos Jéssica Barreto, Maciel Almeida Alessandra, Itria Alexander, Maria Kakehasi Adriana, Alvares Teodoro Juliana, de Assis Acurcio Francisco

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Аннотация

AIM: To evaluate the persistence of biological (TNF inhibitor [anti-TNF]) and synthetic (conventional synthetic disease-modifying antirheumatic drugs [csDMARDs]) antirheumatic agents for psoriatic arthritis and their associated factors.

METHODS

A historical cohort was developed. Persistence and associated factors were evaluated at 6 and 12 months.

RESULTS

A total of 161 patients were included. The anti-TNF treatment presented higher persistence as compared with csDMARDs at 6 (83.4 vs 50.8%; p < 0.05) and 12 months (66.4 vs 35.6%; p < 0.05). From anti-TNFs, adalimumab and etanercept presented similar persistence, along with leflunomide and methotrexate among the csDMARDs. The factors associated with non-persistence with regard to anti-TNF agents were female sex and use of infliximab.

CONCLUSION

Anti-TNF agents are important therapeutic alternatives and present lower rates of discontinuation as compared with csDMARDs.

Для цитирования: Ribeiro da Silva Michael Ruberson, Ribeiro Dos Santos Jéssica Barreto, Maciel Almeida Alessandra, Itria Alexander, Maria Kakehasi Adriana, Alvares Teodoro Juliana, de Assis Acurcio Francisco. Medication persistence for psoriatic arthritis in a Brazilian real-world setting.. Future science OA. 2019. DOI: 10.4155/fsoa-2018-0101.
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