[Evaluation of selected parameters of calcium metabolism in epileptics on long-term treatment with diphenylhydantoin].

In 11 epileptics treated with DPH for 10-20 years a significant fall was observed in the serum levels of calcium, phosphates, and ionic index, with a significant rise in the serum magnesium concentration. No detectable changes were observed in the radiological appearance of bones and alkaline phosphates activity was within normal range. In two cases histological examinations demonstrated signs of osteomalacia. The authors postulate the necessity of monitoring selected parameters of calcium metabolism in patients on long-term treatment with diphenylhydantoin.