American journal of ophthalmology · 2010
Identification of new pathogens in the intraocular fluid of patients with uveitis.
Клинический случайСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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de Groot-Mijnes Jolanda D F, de Visser Lenneke, Zuurveen Stephanie, Martinus Roaldy A, Völker René, ten Dam-van Loon Ninette H, de Boer Joke H, Postma Gina, de Groot Raoul J, van Loon Anton M, Rothova Aniki
Аннотация
PURPOSE: To determine infectious causes in patients with uveitis of unknown origin by intraocular fluids analysis.
DESIGN: Case-control study.
METHODS: Ocular fluids from 139 patients suspected of infectious uveitis, but negative for herpes simplex virus, varicella-zoster virus, cytomegalovirus, and Toxoplasma gondii by polymerase chain reaction and/or antibody analysis in intraocular fluids, were assessed for the presence of 18 viruses and 3 bacteria by real-time polymerase chain reaction (PCR). The ocular fluids from 48 patients with uveitis of known etiology or with cataract were included as controls.
RESULTS: Positive PCR results were found for Epstein-Barr virus, for rubella virus, and for human herpesvirus 6 each in 1 patient and for human parechovirus in 4 patients. Of the human parechovirus-positive patients, 1 was immunocompromised and had panuveitis. The other 3 patients were immunocompetent and had anterior uveitis, all with corneal involvement.
CONCLUSIONS: Human parechovirus might be associated with infectious (kerato)uveitis.
DESIGN: Case-control study.
METHODS: Ocular fluids from 139 patients suspected of infectious uveitis, but negative for herpes simplex virus, varicella-zoster virus, cytomegalovirus, and Toxoplasma gondii by polymerase chain reaction and/or antibody analysis in intraocular fluids, were assessed for the presence of 18 viruses and 3 bacteria by real-time polymerase chain reaction (PCR). The ocular fluids from 48 patients with uveitis of known etiology or with cataract were included as controls.
RESULTS: Positive PCR results were found for Epstein-Barr virus, for rubella virus, and for human herpesvirus 6 each in 1 patient and for human parechovirus in 4 patients. Of the human parechovirus-positive patients, 1 was immunocompromised and had panuveitis. The other 3 patients were immunocompetent and had anterior uveitis, all with corneal involvement.
CONCLUSIONS: Human parechovirus might be associated with infectious (kerato)uveitis.
Предметные рубрики MeSH
AdultAgedAntibodies, ViralAqueous HumorCase-Control StudiesDNA PrimersDNA, ViralEnzyme-Linked Immunosorbent AssayEpstein-Barr Virus InfectionsEye Infections, ViralFemaleFluorescent Antibody Technique, IndirectHerpesvirus 4, HumanHerpesvirus 6, HumanHumansMaleMiddle AgedParechovirusPicornaviridae InfectionsPolymerase Chain ReactionRetrospective StudiesRoseolovirus InfectionsRubellaRubella virusUveitis, Anterior