ADVANCES IN THE GENETICS AND IMMUNOLOGY OF PSORIASIS.

Psoriasis is a chronic, immune-mediated skin condition characterised by keratinocyte hyperproliferation and T cell activation. Prior research has revealed environmental and genetic associations that have contributed to the understanding of psoriasis pathophysiology. Further, this research has contributed to advancements in diagnostics, risk stratification, and therapeutics that impact patient care and health outcomes in psoriasis-associated comorbid conditions such as psoriatic arthritis, metabolic syndrome, and hypertension. Here we review recent advances in psoriasis genetics and immunology.