[Non-opioid analgesics in cancer pain].

Non-opioid analgesics (NSAIDs, acetaminophen) are the most basic drugs used from the first to third steps according to the WHO analgesic ladder. Even after the initiation of the use of opioids, improvement in pain is observed by the continuation of non-opioid analgesics. NSAIDs have anti-inflammatory effects and are particularly effective against somatic pain represented by that due to bone metastasis. On the other hand, NSAIDs should be prescribed with adequate attention being paid to side effects (gastrointestinal disorders and nephropathy) due to long-term administration. Acetaminophen with few side effects is useful for long-term administration, and its use is recommended.