Microbiological Diagnosis: A Key to Successfully Managing Cryptococcal Osteomyelitis Coexisting With Leprosy.

Cryptococcus neoformans, an encapsulated yeast-like fungus, can induce a varied array of symptoms like meningitis, cryptococcomas of the brain, spinal cord granuloma, and disseminated disease, more so in people with impaired immune systems. Nonetheless, osseous lesions are rare. A 27-year-old male presented with a painful ulcer on his left lateral ankle. His medical history revealed leprosy for the last three years. The patient underwent an incisional biopsy and surgical debridement, and both the samples grew Cryptococcus neoformans on culture. Cryptococcal osteomyelitis involving the calcaneus and tibia was established. The patient was treated with liposomal amphotericin B followed by fluconazole. Cryptococcal osteomyelitis, though uncommon, should be included in the differential diagnosis of chronic osteolytic lesions for optimal patient care. This case highlighted that early diagnosis and confirmation through microbiological investigations are crucial for the successful management of these rare and potentially debilitating infections, even in immunocompetent individuals.