Картирование когнитивной дисфункции при повторном склерозе с легкой инвалидностью: перекрестное исследование из Южной Индии.
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Nair Sruthi S, Thulaseedharan Jissa Vinodha, Rajan Neenumol Kandagathparambil, Bava Elshal, Nair Gowthami, Sundaram Soumya, Nair Muralidharan, Kesavadas Chandrasekharan, Menon Ramshekhar N
Аннотация
Оригинал публикации
Mapping cognitive dysfunction in relapsing multiple sclerosis with mild disability: A cross-sectional study from South India.
BACKGROUND: Cognitive dysfunction in multiple sclerosis (MS) occurs early. Locally adapted neuropsychological data from India in MS is scarce.
OBJECTIVES: We aimed to identify the pattern of cognitive impairment in relapsing MS (RMS) with mild disability using a regionally-adapted MS-specific cognitive battery.
METHODOLOGY: The study included 59 persons with MS (pwMS) with expanded disability status scale (EDSS)≤ 4 and 62 controls. The battery had 8 neuropsychological tests (Paced Auditory Serial Addition Test [PASAT], Symbol Digit Modalities Test [SDMT], Rey Auditory Verbal Learning Test [RAVLT], Brief Visuospatial Memory Test-Revised [BVMT-R], verbal fluency [VF], Judgement of Line Orientation Test [JOLOT], Wisconsin Card Sorting Test [WCST] and Trail Making Test-B [TMT-B]) with 11 measures. The scores were compared between the groups for pattern and associations of cognitive impairment.
RESULTS: The pwMS cohort had 39 (66.1%) females; mean age of 32.56 (±8.17) years. Scores were significantly worse for pwMS in 10 of 11 tests (except JOLOT). Cohen's-d test showed the largest effect sizes for PASAT, SDMT, VF and TMT-B. Cognitive impairment (defined as ≥2 abnormal tests) were noted in 41 (69.5%) pwMS. Male sex was associated with cognitive impairment (p = 0.002).
CONCLUSIONS: In pwMS with mild disability, nearly two-thirds had cognitive abnormalities, predominantly involving processing speed, working memory, executive function, and VF.