MedElevator Войти в исследования
← Поиск публикаций

DOI 10.1038/ncomms10531

Медицинская библиотека · Nature communications · 2016

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.

Imamura Minako, Takahashi Atsushi, Yamauchi Toshimasa, Hara Kazuo, Yasuda Kazuki, Grarup Niels, Zhao Wei, Wang Xu, Huerta-Chagoya Alicia, Hu Cheng, Moon Sanghoon, Long Jirong, Kwak Soo Heon, Rasheed Asif, Saxena Richa, Ma Ronald C W, Okada Yukinori, Iwata Minoru, Hosoe Jun, Shojima Nobuhiro, Iwasaki Minaka, Fujita Hayato, Suzuki Ken, Danesh John, Jørgensen Torben, Jørgensen Marit E, Witte Daniel R, Brandslund Ivan, Christensen Cramer, Hansen Torben, Mercader Josep M, Flannick Jason, Moreno-Macías Hortensia, Burtt Noël P, Zhang Rong, Kim Young Jin, Zheng Wei, Singh Jai Rup, Tam Claudia H T, Hirose Hiroshi, Maegawa Hiroshi, Ito Chikako, Kaku Kohei, Watada Hirotaka, Tanaka Yasushi, Tobe Kazuyuki, Kawamori Ryuzo, Kubo Michiaki, Cho Yoon Shin, Chan Juliana C N, Sanghera Dharambir, Frossard Philippe, Park Kyong Soo, Shu Xiao-Ou, Kim Bong-Jo, Florez Jose C, Tusié-Luna Teresa, Jia Weiping, Tai E Shyong, Pedersen Oluf, Saleheen Danish, Maeda Shiro, Kadowaki Takashi

СтатьяМетаанализПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПоддержка правительства СШАПоддержка службы здравоохранения СШАПеревод в очереди

Аннотация

Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 × 10(-8)), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities.

Для цитирования: Imamura Minako, Takahashi Atsushi, Yamauchi Toshimasa, Hara Kazuo, Yasuda Kazuki, Grarup Niels, Zhao Wei, Wang Xu, Huerta-Chagoya Alicia, Hu Cheng, Moon Sanghoon, Long Jirong, Kwak Soo Heon, Rasheed Asif, Saxena Richa, Ma Ronald C W, Okada Yukinori, Iwata Minoru, Hosoe Jun, Shojima Nobuhiro, Iwasaki Minaka, Fujita Hayato, Suzuki Ken, Danesh John, Jørgensen Torben, Jørgensen Marit E, Witte Daniel R, Brandslund Ivan, Christensen Cramer, Hansen Torben, Mercader Josep M, Flannick Jason, Moreno-Macías Hortensia, Burtt Noël P, Zhang Rong, Kim Young Jin, Zheng Wei, Singh Jai Rup, Tam Claudia H T, Hirose Hiroshi, Maegawa Hiroshi, Ito Chikako, Kaku Kohei, Watada Hirotaka, Tanaka Yasushi, Tobe Kazuyuki, Kawamori Ryuzo, Kubo Michiaki, Cho Yoon Shin, Chan Juliana C N, Sanghera Dharambir, Frossard Philippe, Park Kyong Soo, Shu Xiao-Ou, Kim Bong-Jo, Florez Jose C, Tusié-Luna Teresa, Jia Weiping, Tai E Shyong, Pedersen Oluf, Saleheen Danish, Maeda Shiro, Kadowaki Takashi. Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.. Nature communications. 2016. DOI: 10.1038/ncomms10531.

Предметные рубрики MeSH

Asian PeopleCase-Control StudiesDNA-Binding ProteinsDiabetes Mellitus, Type 2Genetic Predisposition to DiseaseGenome-Wide Association StudyHumansJapanPolymorphism, Single NucleotideSuppressor of Cytokine Signaling ProteinsTranscription Factors
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.