Walking-related digital mobility outcomes as clinical trial endpoint measures: protocol for a scoping review.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Polhemus Ashley Marie, Bergquist Ronny, Bosch de Basea Magda, Brittain Gavin, Buttery Sara Catherine, Chynkiamis Nikolaos, Dalla Costa Gloria, Delgado Ortiz Laura, Demeyer Heleen, Emmert Kirsten, Garcia Aymerich Judith, Gassner Heiko, Hansen Clint, Hopkinson Nicholas, Klucken Jochen, Kluge Felix, Koch Sarah, Leocani Letizia, Maetzler Walter, Micó-Amigo M Encarna, Mikolaizak A Stefanie, Piraino Paolo, Salis Francesca, Schlenstedt Christian, Schwickert Lars, Scott Kirsty, Sharrack Basil, Taraldsen Kristin, Troosters Thierry, Vereijken Beatrix, Vogiatzis Ioannis, Yarnall Alison, Mazza Claudia, Becker Clemens, Rochester Lynn, Puhan Milo Alan, Frei Anja
Аннотация
METHODS AND ANALYSIS: Arksey and O'Malley's methodological framework for scoping reviews will guide study conduct. We will search seven databases (Medline, CINAHL, Scopus, Web of Science, EMBASE, IEEE Digital Library and Cochrane Library) and grey literature for studies which (1) measure differences in DMOs between healthy and pathological walking, (2) assess relationships between DMOs and traditional clinical measures, (3) assess the prognostic value of DMOs and (4) use DMOs as endpoints in interventional clinical trials. Two reviewers will screen each abstract and full-text manuscript according to predefined eligibility criteria. We will then chart extracted data, map the literature, perform a narrative synthesis and identify gaps.
ETHICS AND DISSEMINATION: As this review is limited to publicly available materials, it does not require ethical approval. This work is part of Mobilise-D, an Innovative Medicines Initiative Joint Undertaking which aims to deliver, validate and obtain regulatory approval for DMOs. Results will be shared with the scientific community and general public in cooperation with the Mobilise-D communication team.
REGISTRATION: Study materials and updates will be made available through the Center for Open Science's OSFRegistry (https://osf.io/k7395).