Emerging infectious diseases · 2021
Shiga Toxin-Associated Hemolytic Uremic Syndrome in Adults, France, 2009-2017.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Travert Benoît, Dossier Antoine, Jamme Matthieu, Cointe Aurélie, Delmas Yahsou, Malot Sandrine, Wynckel Alain, Seguin Amélie, Presne Claire, Hie Miguel, Benhamou Ygal, Ribes David, Choukroun Gabriel, Grangé Steven, Hertig Alexandre, Le Gall Emilie Cornec, Galicier Lionel, Daugas Eric, Bouadma Lila, Weill François-Xavier, Azoulay Elie, Fakhouri Fadi, Veyradier Agnès, Bonacorsi Stéphane, Hogan Julien, Frémeaux-Bacchi Véronique, Rondeau Eric, Mariani-Kurkdjian Patricia, Coppo Paul, Centre de Référence des Microangiopathies Thrombotiques2
Аннотация
We conducted a retrospective study on hemolytic uremic syndrome caused by Shiga toxin-producing Escherichia coli (STEC) in 96 adults enrolled in the cohort of the National Reference Center for Thrombotic Microangiopathies network in France during 2009-2017. Most infections were caused by STEC strains not belonging to the O157 or O104 serogroups. Thirty (31.3%) patients had multiple risk factors for thrombotic microangiopathy. In total, 61 (63.5%) patients required dialysis, 50 (52.1%) had a serious neurologic complication, 34 (35.4%) required mechanical ventilation, and 19 (19.8%) died during hospitalization. We used multivariate analysis to determine that the greatest risk factors for death were underlying immunodeficiency (hazard ratio 3.54) and severe neurologic events (hazard ratio 3.40). According to multivariate analysis and propensity score-matching, eculizumab treatment was not associated with survival. We found that underlying conditions, especially immunodeficiency, are strongly associated with decreased survival in adults who have hemolytic uremic syndrome caused by STEC.