m+Medelevator.RU
← Поиск публикаций
Frontiers in psychiatry · 2026

Распространение и связанные с этим факторы боязни развития у пациентов с сердечной недостаточностью в Китае: аналитическая оценка.

Название и аннотация: Машинный перевод · не проверен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Wang L, Sun Y, Zuo W, Han Q, Yang L, Guo C, Zhou C

Аннотация

Недостаток сердца (ВФ) является сложным, многофакторным клиническим синдромом с растущей глобальной распространенностью и высокими показателями региотерапии и смертности. Боязнь прогрессирования (ПП) является общей психологической проблемой для пациентов с хроническими заболеваниями, такими, как рак и диабет. Учитывая прогрессивный характер ВЧ, ПФ может представлять не менее важную психологическую проблему для этой группы населения. Она связана с низкой степенью готовности к лечению, снижением качества жизни и более высоким риском неблагоприятных сердечно-сосудистых заболеваний и незапланированной реадмиссией в больницы. Вместе с тем исследования, конкретно посвященные изучению ПФ у пациентов с ВЧ, остаются относительно ограниченными, и имеющиеся данные еще не обобщены на систематической основе. Цель этого аналитического обзора заключалась в картировании инструментов оценки, распространенности и связанных с этим факторов ПФ среди китайских пациентов с помощью ВФ.Методы 2018 Предпочтенные руководящие принципы отчетности по вопросам для системных обзоров и мета-анализа для скопирования обзоров (PRISMA-ScR). Соответствующие исследования были проведены в ten базы данных, включая PubMed, Web of Science Core Collection, Scopus, Embase, CINAHL, CNKI, Wanfang, VIP, CBM и полнотекстовую базу данных CMA с момента создания базы данных по декабрь 31, 2025. Для оценки качества исследований использовались контрольные списки критических оценок Института Джоанны Бриггс. 2,875 записи, и 17 Наконец, были включены исследования из Китая. Эти исследования включали в себя: 3,918 :: пациенты с ВЧ и распространенность ПВП варьировались от 23.40% в адрес 48.00%. Twenty-nine Связанные с этим факторы были определены и сгруппированы в four :: социально-демографические факторы, факторы заболеваний и лечения, психологические и когнитивные факторы, а также факторы здоровья и функциональные факторы. Эти выводы могут способствовать раннему выявлению пациентов с повышенным риском и разработке комплексных стратегий психологической и социальной помощи в рамках управления ВЧ. Будущие исследования должны быть сосредоточены на разработке инструментов оценки, специально предназначенных для ВЧ, понимании того, как со временем меняется ПРП, определении эффективных мер вмешательства и подтверждении этих выводов среди различных географических групп населения.
Оригинал публикации

Prevalence and associated factors of fear of progression in patients with heart failure in China: a scoping review.

IntroductionHeart failure (HF) is a complex, multifactorial clinical syndrome with an increasing global prevalence and high rates of rehospitalization and mortality. Fear of progression (FoP) is a common psychological concern among patients with chronic diseases, such as cancer and diabetes. Given the progressive nature of HF, FoP may represent an equally important psychological concern in this population. It is associated with poor treatment adherence, reduced quality of life, and a higher risk of adverse cardiovascular events and unplanned hospital readmissions. However, studies specifically investigating FoP in patients with HF remain relatively limited, and the existing evidence has not yet been systematically synthesized. This scoping review aimed to map the assessment tools, prevalence, and associated factors of FoP among Chinese patients with HF.MethodsThis scoping review was reported following the 2018 Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines. Relevant studies were searched in ten databases, including PubMed, Web of Science Core Collection, Scopus, Embase, CINAHL, CNKI, Wanfang, VIP, CBM, and CMA Journals Full-text Database, from database inception to December 31, 2025. The Joanna Briggs Institute (JBI) Critical Appraisal Checklists were used to assess the quality of included studies.ResultsThis scoping review identified 2,875 records, and 17 studies from China were finally included. These studies included 3,918 patients with HF, and the prevalence of FoP ranged from 23.40% to 48.00%. Twenty-nine associated factors were identified and grouped into four categories: sociodemographic factors, disease and treatment factors, psychological and cognitive factors, and health and functional factors.ConclusionThis scoping review found that FoP is relatively common in patients with HF in China and is associated with a range of factors. These findings may support early identification of high-risk patients and the development of integrated psychological and social care strategies in HF management. Future research should focus on developing assessment tools specific to HF, understanding how FoP changes over time, identifying effective interventions, and validating these findings across diverse geographical populations.

Перевод полного текста: Перевод в очереди

Читать найденный полный текст

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Introduction

Heart failure (HF) is a clinical syndrome caused by structural or functional abnormalities of the heart and is often characterized by dyspnea, fatigue, and edema ( 1 , 2 ). Population-based studies indicate that the age-standardized global prevalence of HF rose to 676.68 per 100,000 population in 2021 and has increased over time ( 3 ). Recent estimates indicate that about 7.7 million people in the United States and nearly 14.3 million people in China are living with HF ( 4 , 5 ). Furthermore, the one-year readmission rate among patients with HF may reach 35.7%, while the one-year mortality rate may reach 23.3% ( 6 ). As an incurable and progressive chronic disease, HF necessitates rigorous and lifelong self-management, which typically involves daily weight monitoring, fluid and sodium restriction, medication adherence, and the early recognition of decompensation ( 2 ). Despite these efforts, frequent acute exacerbations and repeated hospital readmissions, along with the progressive loss of autonomy, leave patients continuously exposed to illness uncertainty and functional decline ( 7 , 8 ), imposing a severe psychological burden on patients with HF. A recent study exploring the emotional experiences of patients with HF further elucidates the complexity of this psychological distress ( 9 ). In long-term disease management, patients frequently experience helplessness and guilt driven by fear of symptom exacerbation and perceived family burden, leading some to hide their illness to avoid triggering family anxiety. Moreover, adverse life events such as bereavement, divorce, or comorbid severe illnesses often act as powerful emotional triggers. These incidents damage patients’ physical and mental states, heighten emotional fragility, and turn daily self-care into a persistent psychological burden. The combined physical and mental strain caused by these negative events can significantly impair cardiac function.

In recent years, the World Health Organization has urged greater attention to mental health, and many clinical guidelines have highlighted its close link to overall health ( 2 , 10 , 11 ). Fear of progression (FoP), a common adverse psychological response among people living with chronic illnesses such as cancer and diabetes, has received growing academic attention. The concept of FoP was first introduced by Dankert et al. in 2003 ( 12 ). At present, FoP is generally defined as a patient’s subjective perception of disease progression or recurrence and its related negative physical, psychological, and social effects ( 13 ); this disease-specific emotional state differentiates it from the broad clinical anxiety disorders outlined in the International Classification of Diseases, 11th Revision (ICD-11) ( 14 ). However, in the context of HF, FoP extends beyond a general fear of disease progression to encompass profound fears regarding worsening cardiac function, severe dyspnea, functional decline, loss of social roles, dependence on caregivers, and impending death. Importantly, growing evidence suggests that FoP is associated with several adverse outcomes, including reduced adherence to treatment, impaired physical function, reduced quality of life ( 15 , 16 ), delayed return to work ( 17 ), increased psychological distress, and a higher risk of adverse cardiovascular events and unplanned hospital readmissions ( 18 ). Given the progressive nature of HF, FoP may represent an equally important psychological concern in this population. However, evidence on FoP in patients with HF remains limited, and existing studies vary in design, reported prevalence, and associated factors. These inconsistencies make it difficult to obtain a clear understanding of FoP in this population. Therefore, this scoping review aimed to map the available evidence on FoP assessment tools, prevalence, and associated factors among patients with HF. These findings may help healthcare professionals identify patients at high risk and implement targeted psychological interventions, while also supporting the development of FoP-specific assessment tools for this population.

Methods

This scoping review was conducted in accordance with the Arksey and O’Malley framework and reported following the 2018 Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines ( 19 , 20 ). The protocol was registered with the Open Science Framework (OSF; https://doi.org/10.17605/OSF.IO/UY4KH ).

Defining the research questions

Following the PCC framework ( 21 ), with the population defined as patients with HF, the concept as FoP, and the context as associated factors, three research questions were formulated: (1) Which validated tools are available to assess FoP in patients with HF? (2) What is the prevalence of FoP in patients with HF? (3) Which factors are associated with FoP severity in this population?

Inclusion and exclusion criteria

Studies were considered eligible if they met the following criteria: (1) the study population consisted exclusively of adult patients with confirmed HF; (2) FoP was assessed using a validated or clearly described measurement tool; (3) the study reported the prevalence, level, trajectory, or associated factors of FoP in patients with HF; (4) the study was an original quantitative study, including cross-sectional or cohort studies; and (5) the article was published in Chinese or English. Studies were excluded if they were duplicate publications or had incomplete or unavailable data.

Literature search strategy

A systematic literature search was carried out across multiple Chinese and English databases, including PubMed, Web of Science Core Collection, Scopus, Embase, CINAHL, China National Knowledge Infrastructure (CNKI), Wanfang, VIP (Chinese Scientific Journal Database), Chinese Medical Association Journals Full-text Database (CMA Journals Full-text Database), and Chinese Biomedical Literature Database (CBM). The search covered studies published from the start of each database to December 31, 2025. A combination of subject headings and free-text terms was used to develop the search strategy. After eligible studies were identified, citation snowballing was also performed by screening their reference lists. The search query was as follows (using PubMed as an example): (((fear[MeSH Terms]) OR ((Fear*[Title/Abstract]) OR (Cue, Threat[Title/Abstract]) OR (Threat Cue*[Title/Abstract]) OR (Threat Sensitivit*[Title/Abstract]) OR (Sensitivity, Threat[Title/Abstract]))) OR ((Fear of Recurrence[Title/Abstract]) OR (Fear of progression[Title/Abstract]) OR (Disease progression fear[Title/Abstract]) OR (FoP[Title/Abstract]) OR (Fear of Relapse[Title/Abstract]))) AND ((Heart Failure[MeSH Terms]) OR (Heart Failure[Title/Abstract]) OR (Cardiac Failure[Title/Abstract]) OR (Heart Decompensation[Title/Abstract]) OR (Congestive Heart Failure[Title/Abstract]) OR (Myocardial Failure[Title/Abstract])). Detailed search strategies for all databases are provided in the Supplementary Material .

Study selection and data extraction

All identified records were imported into Zotero 7.0 for duplicate removal. Two independent reviewers screened titles and abstracts against the predefined inclusion and exclusion criteria. The full texts of potentially eligible studies were then retrieved and assessed for final inclusion. Any disagreements between the two reviewers were resolved through discussion or by consulting a third reviewer. Data extraction was performed independently by two reviewers using a predesigned data charting form, with discrepancies resolved through discussion or consultation with a third reviewer, and data were extracted for the following variables: study characteristics, sample characteristics, assessment tool, FoP prevalence, and associated factors. Throughout the study, descriptive statistics and narrative reviews were used to organize and synthesize research findings, with thematic analysis utilized to categorize influencing factors ( 22 ).

Quality assessment

Quality appraisal was conducted to describe the methodological quality of the included studies rather than to exclude studies from the review. It was performed using the Joanna Briggs Institute (JBI) Critical Appraisal Checklists for cross-sectional and cohort studies ( 23 ). Each item was rated as “Yes”, “No”, “Unclear”, or “Not applicable”. “Yes” responses were given 1 point, while all others were given 0 points. The total score was converted to a percentage. Studies scoring 85% or above were classified as high quality, whereas those scoring 60% to 84% were considered moderate quality ( 24 ). The quality assessment was conducted independently by two reviewers, and any differences were addressed through discussion with a third reviewer.

Results

Study selection

A systematic search was conducted across multiple databases from their inception to December 31, 2025, and the final search was conducted on January 31, 2026, identifying 2,875 records. After duplicates were removed and the titles, abstracts, and full texts were screened, 17 studies were finally included. Details are shown in Figure 1 .

Figure 1 Flow chart of the search strategy and study selection process. Flow chart illustrating a literature review process with three phases: Identification, Screening, and Inclu…
Figure 1 Flow chart of the search strategy and study selection process. Flow chart illustrating a literature review process with three phases: Identification, Screening, and Included. Out of 2,875 records identified from several databases, 1,371 duplicates were removed. Next, 1,504 records were screened by title and abstract, excluding 1454 irrelevant or duplicate-language/review records. Fifty reports were assessed for eligibility, with 33 excluded for overlapping databases or not discussing factors influencing fear of progression in heart failure. Seventeen studies were ultimately included. Reference tracking added zero additional studies.

Study characteristics

This scoping review included 17 studies ( 18 , 25 – 40 ), all conducted in China and published between 2021 and 2025 ( Table 1 ; Figure 2 ). Of these, 14 were published in Chinese ( 18 , 25 – 32 , 36 – 40 ) and three in English ( 33 – 35 ). Regarding study design, 15 were cross-sectional studies ( 25 – 37 , 39 , 40 ) and two were cohort studies ( 18 , 38 ). Ten were single-center studies ( 25 – 29 , 35 – 38 , 40 ), whereas seven were multicenter studies ( 18 , 30 – 34 , 39 ). Four studies enrolled only patients aged 60 years or older ( 27 , 31 , 34 , 36 ), and one focused specifically on patients in the vulnerable phase of HF ( 30 ). Among the 17 included studies, 3,918 participants were included in total. Each study enrolled between 120 and 362 participants, and the proportion of female participants ranged from 33.19% to 52.43%.

Table 1
Characteristics of included studies.
1. *Patients were classified into the high-FoP group using LPA or LGM. 2. NA, Not available. 3. Associated Factors: 1. Age, 2. Gender, 3. Residence, 4. Education level, 5. Household income level, 6. Health insurance type, 7. Number of hospitalizations, 8. Comorbidity count, 9. NYHA functional classification, 10. Disease duration, 11. LVEF, 12. Number of oral medications, 13. New-onset HF, 14. Depression, 15. Anxiety, 16. Self-efficacy, 17. Illness perception, 18. Social support, 19. Psychological resilience, 20. Self-care confidence, 21. Level of self-disclosure, 22. Sleep quality, 23. Quality of life, 24. Health literacy, 25. Symptom perception, 26. Perceived family support, 27. Meaning in life, 28. Activities of daily living, 29. Coping style.

AuthorStudy designYearStudy regionSample sourceAge (years)Sample sizeFemale (%)Assessment toolFoP score, mean ± SDFoP prevalence (%)Associated factors
Du et al. ( 25 )Cross-sectional study2021Heilongjiang, ChinaSingle-center≥1815043.33FoP-Q-SF31.89 ± 6.2241.3016;18
Cao Y et al. ( 26 )Cross-sectional study2022Jiangsu, ChinaSingle-center≥1819836.86FoP-Q-SF31.97 ± 8.9644.449;11;16
Xiong et al. ( 18 )Cohort study2023Jiangsu, ChinaMulticenter≥1826744.19FoP-Q-SF30.54 ± 6.5334.201;12;19;20;25
Zhao et al. ( 27 )Cross-sectional study2023Jiangsu, ChinaSingle-center≥6022351.56FoP-Q-SF33.30 ± 7.0048.005;8;9;10;11;16;18
Hu et al. ( 28 )Cross-sectional study2024Shandong, ChinaSingle-center≥1830537.70FoP-Q-SF35.30 ± 4.8036.071;2;9;10;18;21;25
Huang et al. ( 29 )Cross-sectional study2024Shandong, ChinaSingle-center≥1815042.66FoP-Q-SF21.03 ± 6.30NA22
Tang Q et al. ( 30 )Cross-sectional study2024Guangxi, ChinaMulticenter≥1824038.33FoP-Q-SF32.70 ± 3.5038.70*1;8;13;18;24
Zhu et al. ( 31 )Cross-sectional study2024Sichuan, ChinaMulticenter≥60320NAFoP-Q-SF34.31 ± 8.3928.43*3;6;8;16;25
Cao M ( 32 )Cross-sectional study2024Shandong, ChinaMulticenter≥1821444.39FoP-Q-SF32.75 ± 8.0137.851;9;10;11
Qu ( 37 )Cross-sectional study2024Liaoning, ChinaSingle-center≥1824133.19FoP-Q-SF28.77 ± 8.4531.5416;26;27
Chen et al. ( 33 )Cross-sectional study2025Henan, ChinaMulticenter≥1827740.43FoP-Q-SF23.91 ± 7.66NA23
Tian et al. ( 34 )Cross-sectional study2025Hebei, ChinaMulticenter≥6024846.77FoP-Q-SF28.43 ± 0.4723.4017;18;19
Li et al. ( 35 )Cross-sectional study2025Jiangsu, ChinaSingle-center≥1824652.43FoP-Q-SF29.52 ± 7.03NA22
Ma et al. ( 36 )Cross-sectional study2025Shaanxi, ChinaSingle-center≥6020351.72FoP-Q-SF32.98 ± 10.1547.787;16;18;23
Sun et al. ( 38 )Cohort study2025Jiangsu, ChinaSingle-center≥18154NAFoP-Q-SF37.19 ± 6.7240.90*1;7;9;14;15;16;18
Tang Y. et al. ( 39 )Cross-sectional study2025Anhui, ChinaMulticenter≥1836243.37FoP-Q-SF32.70 ± 10.20NA23
Xu et al. ( 40 )Cross-sectional study2025Shandong, ChinaSingle-center≥1812041.66FoP-Q-SF30.58 ± 3.5134.174;7;8;10;28;29
Figure 2 Distribution of study regions. The outer ring shows the categorization of the four major regions. The inner ring details the provinces included in this study. Specific pr…
Figure 2 Distribution of study regions. The outer ring shows the categorization of the four major regions. The inner ring details the provinces included in this study. Specific proportions for Jiangsu and Shandong are labeled, while all other provinces are represented by equal, smaller segments. 3D doughnut chart displaying proportions of regions and provinces in China. Outer ring shows Northeast China and Central China at eleven point eight percent each, Western China at seventeen point six percent, and Eastern China at fifty-eight point eight percent. Inner sections detail provinces, with Jiangsu at twenty-nine point four percent and Shandong at twenty-three point five percent. Other provinces, including Anhui, Heilongjiang, Liaoning, Henan, Hebei, Guangxi, Sichuan, and Shaanxi, each account for the same smaller proportion.

FoP assessment tools

All included studies used the Fear of Progression Questionnaire-Short Form (FoP-Q-SF) to assess FoP. The FoP-Q-SF was adapted from the original Fear of Progression Questionnaire (FoP-Q). It has been applied in patients with various chronic conditions, including cancer, diabetes, and heart disease ( 41 , 42 ), and is widely validated as a unidimensional measure ( 43 , 44 ). In 2015, Wu Qiyun translated the FoP-Q-SF into Chinese ( 45 ). However, the Chinese version comprises 12 items across two dimensions, namely physical health and social/family functioning. It uses a 5-point Likert scale, with responses ranging from 1 (never) to 5 (always). Scores range from 12 to 60. A score of 34 or higher suggests clinically significant FoP, and a higher score indicates more severe FoP ( 33 , 46 ). The Chinese version showed good reliability, with Cronbach’s α values of 0.883 for the total scale, 0.829 for the physical health dimension, and 0.812 for the social/family dimension.

Current status of FoP in HF

All included studies reported the mean FoP-Q-SF scores in patients with HF, which ranged from 21.03 to 37.19. Among these, eight studies reported scores for the two dimensions of the FoP-Q-SF. Seven studies ( 18 , 25 , 28 , 32 , 35 , 37 , 39 ) showed that patients scored higher on the physical health dimension than on the social/family dimension, whereas one study ( 29 ) reported the opposite finding. Ten studies ( 18 , 25 – 28 , 32 , 34 , 36 , 37 , 40 ) indicated that the proportion of patients with FoP-Q-SF scores of ≥34 ranged from 23.40% to 48.00%. Three additional studies used latent variable approaches to examine FoP, including latent profile analysis (LPA) in two studies ( 30 , 31 ) and latent growth model (LGM) in one study ( 38 ). The proportion of patients classified into the high-FoP group ranged from 28.43% to 40.90%. Two studies ( 18 , 38 ) conducted follow-up assessments at 3 and 6 months post-discharge and found that FoP levels gradually decreased over time. Three studies ( 18 , 25 , 32 ) showed that higher FoP-Q-SF scores were consistently associated with the item “Worry about what would happen to my family if something happened to me”.

Associated factors of FoP in HF

Twenty-nine factors associated with FoP in patients with HF were identified from the included studies and grouped into four main categories, as shown in Figures 3 , 4 and Table 2 .

Figure 3 Word cloud of factors associated with FoP in patients with HF. Word size reflects the frequency of occurrence of each factor. Word cloud graphic displaying health-related…
Figure 3 Word cloud of factors associated with FoP in patients with HF. Word size reflects the frequency of occurrence of each factor. Word cloud graphic displaying health-related terms with varying prominence and colors; largest words include Self-efficacy, Social support, NYHA functional classification, Comorbidity count, Quality of life, Disease duration, and Age.
Figure 4 Factors associated with FoP in patients with HF. Arrows indicate the direction of association with FoP (↑ Positive association; ↓ Negative association; ↕ Mixed findings (…
Figure 4 Factors associated with FoP in patients with HF. Arrows indicate the direction of association with FoP (↑ Positive association; ↓ Negative association; ↕ Mixed findings (both positive and negative associations reported). Circular infographic illustrating associated factors of fear of progression (FoP) in heart failure (HF), divided into four sections: sociodemographic, disease and treatment, psychological and cognitive, and health and functional, each listing relevant contributing factors with directional arrows indicating influence.

Table 2
Comprehensive mapping table of associated factors and included studies regarding FoP in HF.

Factor categoryAssociated factorsIncluded studies
Positive associationNegative association
Sociodemographic factorsAgeSun et al. ( 38 )Xiong ( 18 ); Hu et al. ( 28 ); Tang Q et al. ( 30 ); Cao M ( 32 )
GenderHu et al. ( 28 )
ResidenceZhu et al. ( 31 )
Education levelXu et al. ( 40 )
Household income levelZhao et al. ( 27 )
Perceived family supportQu ( 37 )
Health insurance typeZhu et al. ( 31 )
Social supportDu et al. ( 25 ); Zhao et al. ( 27 ); Hu et al. ( 28 ); Tang Q et al. ( 30 ); Tian et al. ( 34 ); Ma et al. ( 36 ); Sun et al. ( 38 )
Disease and treatment factorsNumber of hospitalizationsMa et al. ( 36 ); Sun et al. ( 38 ); Xu et al. ( 40 )
Comorbidity countZhao et al. ( 27 ); Tang Q et al. ( 30 ); Zhu et al. ( 31 ); Xu et al. ( 40 )
NYHA functional classificationCao Y et al. ( 26 ); Zhao et al. ( 27 ); Hu et al. ( 28 ); Cao M ( 32 ); Sun et al. ( 38 )
LVEFCao Y et al. ( 26 ); Zhao et al. ( 27 ); Cao M ( 32 )
Disease durationZhao et al. ( 27 ); Hu et al. ( 28 ); Xu et al. ( 40 )Cao M ( 32 )
Number of oral medicationsXiong ( 18 )
New-onset HFTang Q et al. ( 30 )
Symptom perceptionXiong ( 18 ); Hu et al. ( 28 ); Zhu et al. ( 31 )
Psychological and cognitive factorsDepressionSun et al. ( 38 )
AnxietySun et al. ( 38 )
Self-efficacyDu et al. ( 25 ); Cao Y et al. ( 26 ); Zhao et al. ( 27 ); Zhu et al. ( 31 ); Ma et al. ( 36 ); Qu ( 37 ); Sun et al. ( 38 )
Psychological resilienceXiong ( 18 ); Tian et al. ( 34 )
Self-care confidenceXiong ( 18 )
Level of self-disclosureHu et al. ( 28 )
Health literacyTang Q et al. ( 30 )
Meaning in lifeQu ( 37 )
Coping styleXu et al. ( 40 )
Illness perceptionTian et al. ( 34 )
Health and functional factorsSleep qualityHuang et al. ( 29 ); Li et al. ( 35 )
Quality of lifeChen et al. ( 33 ); Ma et al. ( 36 ); Tang Y et al. ( 39 )
Activities of daily livingXu et al. ( 40 )

Sociodemographic factors

Several sociodemographic factors were associated with FoP in patients with HF. Four studies ( 18 , 28 , 30 , 32 ) reported higher FoP in middle-aged and younger patients than in older patients, whereas Sun et al. ( 38 ) reported the opposite finding. One study ( 28 ) found higher FoP in women than in men. Zhu et al. ( 31 ) reported that patients living in urban areas had lower FoP. In addition, patients covered by Basic Medical Insurance for Urban Workers had lower FoP than those covered by Basic Medical Insurance for Urban and Rural Residents. Xu et al. ( 40 ) found that an education level of junior high school or below was a risk factor for higher FoP. One study ( 27 ) indicated that patients with low income had higher FoP. Seven studies ( 25 , 27 , 28 , 30 , 34 , 36 , 38 ) showed a significant negative correlation between FoP and social support. Another study ( 37 ) similarly found that perceived family support was negatively correlated with FoP.

Disease and treatment factors

Three studies ( 36 , 38 , 40 ) showed that more frequent hospitalizations were associated with higher FoP in patients with HF. Four studies ( 27 , 30 , 31 , 40 ) reported a positive correlation between comorbidity burden and FoP. Cardiac function status was associated with FoP severity. Five studies ( 26 – 28 , 32 , 38 ) found a positive correlation between New York Heart Association (NYHA) functional classification and FoP, and three studies ( 26 , 27 , 32 ) reported higher FoP in patients with reduced left ventricular ejection fraction (LVEF). Disease duration was also associated with FoP. Three studies ( 27 , 28 , 40 ) indicated that FoP increased with longer disease duration, whereas Cao M ( 32 ) reported higher FoP in patients with a disease duration of less than one year. Xiong ( 18 ) found that a greater number of oral medications was associated with higher FoP, and Tang Q et al. ( 30 ) identified new-onset HF as an additional risk factor. Three studies ( 18 , 28 , 31 ) showed that more severe symptom perception, defined as patients’ evaluation of physical symptoms and the associated distress, was associated with higher self-reported FoP.

Psychological and cognitive factors

Among the 17 included studies, Sun et al. ( 38 ) observed that elevated levels of depression and anxiety were correlated with higher FoP in patients with HF. Seven studies ( 25 – 27 , 31 , 36 – 38 ) demonstrated a significant inverse correlation between FoP and self-efficacy. Psychological resilience was defined as the ability to return to a normal functional state following illness or trauma; two studies ( 18 , 34 ) showed a negative association between psychological resilience and FoP. Xiong ( 18 ) found lower FoP in patients with higher self-care confidence. Hu et al. ( 28 ) reported that patients’ self-disclosure level was negatively related to FoP. Tang Q et al. ( 30 ) reported that high health literacy was associated with lower FoP. Qu ( 37 ) found that a stronger sense of meaning in life was associated with lower FoP. Xu et al. ( 40 ) found that a negative coping style was associated with higher FoP. Illness perception, which reflects patients’ cognitive and emotional understanding of illness ( 47 ), was also positively correlated with FoP ( 34 ).

Health and functional factors

Two studies ( 29 , 35 ) found that poorer sleep quality reported by patients with HF was associated with more severe FoP. Three studies ( 33 , 36 , 39 ) reported that patients with poorer quality of life had higher FoP. Xu et al. ( 40 ) noted that patients with poorer activities of daily living (ADL) and greater care dependency had higher levels of FoP.

Quality assessment results

Based on the JBI Critical Appraisal Checklists, 13 of the 17 included studies achieved a perfect score of 100%, 2 scored 90.9%, and 2 scored 75%. Overall, 15 studies (88.2%) were rated as high quality. Detailed quality assessment results are presented in Table 3 and Table 4 .

Table 3
Quality assessment of cross−sectional studies based on the JBI Critical Appraisal Checklist.

ItemsDu et al. ( 25 )Cao Y et al. ( 26 )Zhao et al. ( 27 )Hu et al. ( 28 )Huang et al. ( 29 )Tang Q et al. ( 30 )Zhu et al. ( 31 )Cao M ( 32 )Chen et al. ( 33 )Tian et al. ( 34 )Li et al. ( 35 )Ma et al. ( 36 )Qu ( 37 )Tang Y et al. ( 39 )Xu et al. ( 40 )
1. Were the criteria for inclusion in the sample clearly defined?YESYESYESYESYESYESYESYESYESYESYESYESYESYESYES
2. Were the study subjects and the setting described in detail?YESYESYESYESYESYESYESYESYESYESYESYESYESYESYES
3. Was the exposure measured in a valid and reliable way?YESYESYESYESYESYESYESYESYESYESYESYESYESYESYES
4. Were objective, standard criteria used for measurement of the condition?YESYESYESYESYESYESYESYESYESYESYESYESYESYESYES
5. Were confounding factors identified?NOYESYESYESYESYESYESYESYESYESYESYESYESNOYES
6. Were strategies to deal with confounding factors stated?NOYESYESYESYESYESYESYESYESYESYESYESYESNOYES
7. Were the outcomes measured in a valid and reliable way?YESYESYESYESYESYESYESYESYESYESYESYESYESYESYES
8. Was appropriate statistical analysis used?YESYESYESYESYESYESYESYESYESYESYESYESYESYESYES
Total score688888888888868
Percentage of maximum score75%100%100%100%100%100%100%100%100%100%100%100%100%75%100%

Table 4
Quality assessment of cohort studies based on the JBI Critical Appraisal Checklist.

ItemsXiong ( 18 )Sun et al. ( 38 )
1. Were the two groups similar and recruited from the same population?YESYES
2. Were the exposures measured similarly to assign people to both exposed and unexposed groups?YESYES
3. Was the exposure measured in a valid and reliable way?YESYES
4. Were confounding factors identified?YESYES
5. Were strategies to deal with confounding factors stated?YESYES
6. Were the groups/participants free of the outcome at the start of the study (or at the moment of exposure)?YESYES
7. Were the outcomes measured in a valid and reliable way?YESYES
8. Was the follow up time reported and sufficient to be long enough for outcomes to occur?YESYES
9. Was follow up complete, and if not, were the reasons to loss to follow up described and explored?YESYES
10. Were strategies to address incomplete follow up utilized?NONOT APPLICABLE
11. Was appropriate statistical analysis used?YESYES
Total score1010
Percentage of maximum score90.9%90.9%

Discussion

The negative clinical consequences of FoP in patients with HF are governed by several underlying mechanisms. Firstly, FoP acts as a persistent psychological stressor capable of hyperactivating the sympathetic nervous system and the hypothalamic-pituitary-adrenal (HPA) axis ( 48 ). This physiological cascade ultimately exacerbates systemic inflammation, raises the risk of cardiovascular events, and accelerates HF progression ( 49 ). Secondly, persistent high FoP contributes to maladaptive avoidance behaviors, most notably kinesiophobia. Holding the false belief that physical activity or work-related strain can trigger HF exacerbation or sudden cardiac death, patients voluntarily limit physical participation. This behavioral restriction constrains routine daily living, prolongs work absence, and accelerates physical deconditioning ( 22 ). Thirdly, high FoP leads to somatic amplification and catastrophic thinking ( 50 ). Patients tend to mistake normal bodily sensations for HF progression. This psychological burden leads to poor treatment adherence, as patients may intentionally skip medications to avoid illness reminders or misinterpret side effects as a worsening condition ( 15 ). Such constant hypervigilance impairs quality of life and increases mental distress. Furthermore, excessive worry about physical symptoms drives unnecessary healthcare utilization, resulting in frequent unplanned medical visits.

Given these complex mechanisms and their adverse impacts, a comprehensive understanding of current FoP research is essential. Therefore, this scoping review synthesized evidence from 17 eligible studies and provided a comprehensive overview of FoP assessment tools, prevalence, and associated factors among patients with HF. The main findings are as follows:

Limited availability of HF-specific FoP assessment tools

All studies included in this scoping review employed the FoP-Q-SF to measure FoP. Although this may have enhanced the consistency of findings to some extent, it also highlights the current shortage of disease-specific assessment tools for this population. The development of FoP-related assessment tools for cardiac populations remains limited. In 2021, Li developed the FoP scale for patients with acute myocardial infarction, comprising 17 items across three dimensions ( 51 ). In 2025, Clarke et al. developed the Cardiac Recurrence and Progression Fear Scale and applied it in patients with heart disease ( 52 , 53 ). As of December 2025, no dedicated assessment tools have been developed specifically for FoP in patients with HF.

Common occurrence of FoP and prominent concerns about physical health

FoP-Q-SF scores in patients with HF ranged from 21.03 to 37.19, with an upper range lower than that reported in patients with breast cancer (23.57–45.79) ( 54 ). Meanwhile, the prevalence of FoP in patients with HF ranged from 23.40% to 48.00%, with nearly one-third of the studies reporting a prevalence exceeding 40%, which is substantially higher than the 23.10% to 35.80% range reported in diabetic populations ( 55 , 56 ). These findings suggest that FoP is a common psychological concern among patients with HF in the available Chinese literature, warranting greater attention from clinicians and researchers. Patients with HF scored higher on the physical health dimension than on the social/family dimension of the FoP-Q-SF, indicating greater concern about disease progression and treatment-related risks. A similar pattern has been reported in gastric cancer research ( 57 ). This dimensional difference may be explained by the progressive nature of HF. Symptoms such as chest tightness, dyspnea, and fatigue may gradually become worse, affecting daily functioning and overall health, and lead to psychological distress ( 58 ). The level of FoP gradually declines with time since discharge, which may be attributed to better adaptation to the disease and its treatment, alleviation of physical symptoms, stabilization of psychological status, improved self-management abilities, and greater perceived control over the disease ( 59 ). Patients scored higher on the FoP-Q-SF item “Worry about what would happen to my family if something happened to me,” likely because of their central role in the family and concerns about not fulfilling family responsibilities or placing a greater burden on relatives after disease onset. Accordingly, healthcare professionals should routinely monitor FoP upon admission and at 3 and 6 months post-discharge to identify psychological distress early and enable tailored interventions. Such screening is particularly crucial for patients with high symptom burden or central family roles. Meanwhile, optimizing physical symptom management and self-management education during these follow-ups can enhance patients’ perceived control over the disease and alleviate FoP.

Multidimensional factors associated with FoP in patients with HF

Sociodemographic factors

Most studies indicated that younger and middle-aged patients with HF tend to report higher levels of FoP, similar to breast cancer patients ( 54 ), likely due to their significant family and work responsibilities, combined with relatively limited life experience and lower psychological resilience ( 60 ). Adequate social support can help patients reintegrate into the workforce while maintaining and improving their overall physical and mental health. Emotional support from family, friends, and social networks, in particular, provides comfort and understanding and may help alleviate feelings of loneliness and anxiety ( 61 ). Accordingly, social support may help alleviate FoP in this patient population, which is consistent with findings in patients with multiple sclerosis ( 62 ). Household income is a key determinant of patients’ medical expenses and financial security in daily life. Low-income patients face substantial financial burdens due to prolonged treatment costs and reduced work capacity, which may increase their FoP and uncertainty about future health outcomes ( 63 ). Therefore, healthcare professionals should prioritize younger and middle-aged patients, those with insufficient social support, and those facing financial hardship by facilitating their access to healthcare resources and support services. For example, individualized health education programs on disease self-management, diet, and exercise can be tailored to patients’ age and income and provided in various formats, such as videos, illustrations, and written materials. Home visits may be arranged when necessary.

Disease and treatment factors

Patients with multiple chronic comorbidities not only face challenges in treatment planning and disease prognosis but also experience more severe physical symptoms, faster disease progression, and a higher risk of adverse treatment reactions and complications ( 64 ). These factors may complicate clinical assessment, heighten illness-related concerns ( 27 , 30 , 40 ), and increase the risk of FoP. Similar associations between a higher comorbidity burden and elevated FoP have also been reported in patients with diabetes ( 55 ). NYHA functional class and LVEF are key indicators of HF severity. A higher NYHA functional class or lower LVEF indicates more severe disease and more pronounced symptoms such as dyspnea and fatigue. Daily life and work may also be more limited. More severe disease is often associated with a poorer prognosis, which may increase patients’ uncertainty regarding their condition. This may lead to negative emotions such as anxiety and depression, thereby increasing the likelihood of FoP ( 26 – 28 , 32 , 38 ). Therefore, healthcare professionals should use online health management platforms for remote monitoring and timely follow-up, which may help detect early signs of worsening, facilitate prompt interventions, reduce acute exacerbations, and improve long-term quality of life and clinical outcomes.

Psychological and cognitive factors

Self-efficacy has received increasing attention in recent research. It refers to an individual’s confidence in their ability to organize and carry out the actions needed to achieve their goals ( 65 ). Patients with higher self-efficacy can better cope with disease-related stress, adopt active disease management strategies, and maintain a stronger sense of control over their illness. This may help them better adjust to illness perceptions and emotional states and reduce FoP to some extent ( 66 ). By contrast, patients with low self-efficacy may interpret disease-related information more negatively and make less use of available social support, which may lead to higher FoP. Therefore, healthcare professionals should assess and enhance patients’ self-efficacy at an early stage to help alleviate FoP.

Health and functional factors

Patients with poor quality of life often have weakened cardiac function and severe physical symptoms. These factors keep them under long-term psychological stress and may increase their FoP. Therefore, healthcare professionals should provide targeted health education and encourage these patients to adopt proactive coping strategies, which can help reduce psychological distress and improve overall mental well-being.

Interrelationships among factors associated with FoP

Existing literature suggests that the identified factors are closely connected rather than acting independently. For example, patients’ sociodemographic characteristics, clinical conditions, and quality of life are all linked to their psychological states. Effective social support not only improves psychological resilience but may also help reduce anxiety and depression to some extent ( 67 ). Furthermore, educational level and disease self-management may significantly affect patients’ self-efficacy ( 68 ). Therefore, HF management should include comprehensive evaluations of patients’ social, psychological, clinical, and functional status, together with individualized interventions to reduce FoP and support overall physical and mental health.

Clinical implications

While FoP is a prevalent psychological burden across various chronic diseases, its manifestations differ markedly by disease trajectory. Patients with cancer or diabetes tend to have stable worries about foreseeable adverse outcomes. Cancer patients fear tumor recurrence and metastasis, while diabetic patients focus on the strict lifelong medical management ( 56 ). These worries are strongly associated with slow disease progression or treatment-related adverse effects. In contrast, FoP in HF arises from unpredictable cardiac dysfunction and the risk of abrupt acute decompensation ( 69 ). This unpredictability triggers prominent somatic hypervigilance, causing patients to often misread mild dyspnea or fatigue as signals of rapid cardiac deterioration or impending death. This distinction suggests that FoP in HF is a dynamic, symptom-driven psychological state rather than a static fear of a discrete event. In this context, the findings of this scoping review offer significant clinical implications. First, this study systematically identified and synthesized 29 factors associated with FoP in patients with HF. These findings can help identify patients at high risk early and support targeted psychological interventions in clinical practice. Second, the results highlighted that FoP arises from the interaction of social, clinical, and psychological factors, providing a theoretical foundation for future research to design multicomponent interventions targeting FoP. Finally, this scoping review may support a shift in HF care from a purely physiological focus toward an approach that better integrates psychological and social rehabilitation.

Limitations of the study

First, most studies included in this scoping review were cross-sectional (88.23%), which limited the ability to capture changes in FoP over time. Second, this scoping review included only formally published studies in Chinese and English and did not search for gray literature, which may have resulted in the omission of real-world clinical intervention experiences and introduced potential publication bias. Third, all included studies were conducted in China, which may reflect cross-country differences in attention to FoP among patients with HF. Therefore, caution is warranted when generalizing these findings to populations in other countries or cultural contexts. Fourth, compared with a meta-analysis, this scoping review did not provide pooled effect sizes, which may limit the direct applicability of the findings to clinical practice.

Directions for future studies

Future research should utilize longitudinal designs to focus on the dynamic patterns of FoP in patients with HF across different HF stages and social contexts, and to explore its causal relationships with morbidity, prognosis, and health-related quality of life (HRQoL). Secondly, well-designed intervention studies should be undertaken to develop and evaluate targeted nursing strategies that aim to reduce FoP in this population and provide evidence-based support for integrated psychological care. Finally, while the FoP-Q-SF is useful for cross-study comparisons, it lacks sensitivity to HF-specific concerns, such as acute decompensation, sudden cardiac death, readmissions, and declining cardiac function. Therefore, developing HF-specific tools is essential to enhance screening and risk stratification, yet this approach demands extensive validation and inevitably limits cross-disease comparability.

Conclusion

This scoping review shows that FoP is relatively common among patients with HF and is influenced by factors in four main areas: sociodemographic characteristics, disease and treatment conditions, psychological and cognitive factors, and health and functional status. These findings may help healthcare professionals better identify patients at high risk of FoP and promote HF care that goes beyond physical rehabilitation to include psychological and social rehabilitation. Future research should focus on understanding how FoP changes over time and identifying effective interventions. In addition, assessment tools specific to HF should be developed to support both clinical practice and research in this field. Finally, studies across broader geographical and cultural contexts are needed to validate and expand upon these findings.

Acknowledgments

We thank the editorial committees for their assistance in the writing of this study.

Funding Statement

The author(s) declared that financial support was not received for this work and/or its publication.

Footnotes

Edited by: Andreas Dinkel , Technical University of Munich, Germany

Reviewed by: Dina Di Giacomo , University of L'Aquila, Italy

Christian Albus , University Hospital of Cologne, Germany

Mohammed Alanazi , University of Bisha, Saudi Arabia

Author contributions

LW: Conceptualization, Data curation, Supervision, Visualization, Writing – original draft. YS: Methodology, Project administration, Writing – original draft. WZ: Data curation, Writing – original draft. QH: Conceptualization, Formal analysis, Writing – original draft. LY: Investigation, Validation, Writing – review & editing. CG: Methodology, Project administration, Writing – review & editing. CZ: Conceptualization, Methodology, Project administration, Writing – review & editing.

Conflict of interest

The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Generative AI statement

The author(s) declared that generative AI was not used in the creation of this manuscript.

Any alternative text (alt text) provided alongside figures in this article has been generated by Frontiers with the support of artificial intelligence and reasonable efforts have been made to ensure accuracy, including review by the authors wherever possible. If you identify any issues, please contact us.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Supplementary material

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fpsyt.2026.1865683/full#supplementary-material

References

1. Beghini A, Sammartino AM, Papp Z, von Haehling S, Biegus J, Ponikowski P, et al. 2024 update in heart failure. ESC Heart Fail. (2024) 12:8–42. doi: 10.1002/ehf2.14857

2. Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: Executive summary: A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. (2022) 145:e876–94. doi: 10.1161/CIR.0000000000001062

3. Ran J, Zhou P, Wang J, Zhao X, Huang Y, Zhou Q, et al. Global, regional, and national burden of heart failure and its underlying causes, 1990–2021: results from the global burden of disease study 2021. biomark Res. (2025) 13:16. doi: 10.1186/s40364-025-00728-8

4. Yang X, Zhao Z, Shi Y, Han G, Xu Y, Li Y, et al. The evolving burden of heart failure in China: a 34-year subnational analysis of trends and causes from the Global Burden of Disease Study 2023. Mil Med Res. (2025) 12:65. doi: 10.1186/s40779-025-00650-y

5. Palaniappan LP, Allen NB, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, et al. 2026 heart disease and stroke statistics: A report of US and global data from the American Heart Association. Circulation. (2026) 153:e275–906. doi: 10.1161/CIR.0000000000001412

6. Foroutan F, Rayner DG, Ross HJ, Ehler T, Srivastava A, Shin S, et al. Global comparison of readmission rates for patients with heart failure. J Am Coll Cardiol. (2023) 82:430–44. doi: 10.1016/j.jacc.2023.05.040

7. Koontalay A, Botti M, Hutchinson A. Illness perceptions of people living with chronic heart failure and limited community disease management. J Clin Nurs. (2024) 33:4100–11. doi: 10.1111/jocn.17335

8. Suarez L, Hughes C, Ehlers S, Dunlay SM, Staab JP. Illness perceptions and emotional experiences in heart failure: Qualitative insights to inform personalized psychosocial care. J Acad Consult Liaison Psychiatry. (2026) 67:14–25. doi: 10.1016/j.jaclp.2025.10.330

9. Di Giacomo D, Cilli E, Guerra F, Barbati F, Petroni R, Sciarra L, et al. Stressful life events and heart failure: A mixed-method study to analyze the patient’s perspective. Cardiol Ther. (2025) 14:199–217. doi: 10.1007/s40119-025-00406-8

10. Bueno H, Deaton C, Farrero M, Forsyth F, Braunschweig F, Buccheri S, et al. 2025 ESC clinical consensus statement on mental health and cardiovascular disease: Developed under the auspices of the ESC Clinical Practice Guidelines Committee: Developed by the task force on mental health and cardiovascular disease of the European Society of Cardiology (ESC) Endorsed by the European Federation of Psychologists’ Associations AISBL (EFPA), the European Psychiatric Association (EPA), and the International Society of Behavioral Medicine (ISBM). Eur Heart J. (2025) 46:4156–225. doi: 10.1093/eurheartj/ehaf191

11. Freeman M. The World Mental Health Report: transforming mental health for all. World Psychiatry. (2022) 21:391–2. doi: 10.1002/wps.21018

12. Dankert A, Duran G, Engst-Hastreiter U, Keller M, Waadt S, Henrich G, et al. Fear of progression in patients with cancer, diabetes mellitus and chronic arthritis. Rehabilitation. (2003) 42:155–63. doi: 10.1055/s-2003-40094

13. Waldenburger N, Steinecke M, Peters L, Jünemann F, Bara C, Zimmermann T. Depression, anxiety, fear of progression, and emotional arousal in couples after left ventricular assist device implantation. ESC Heart Fail. (2020) 7:3022–8. doi: 10.1002/ehf2.12927

14. World Health Organization . International Classification of Diseases, 11th Revision (2022). Available online at: https://icd.who.int/browse11/l-m/en (Accessed January 13, 2026).

15. Sharpe L, Michalowski M, Richmond B, Menzies RE, Shaw J. Fear of progression in chronic illnesses other than cancer: a systematic review and meta-analysis of a transdiagnostic construct. Health Psychol Rev. (2022) 17:301–20. doi: 10.1080/17437199.2022.2039744

16. Westas M, Melnikov S. Prevalence and outcomes of fears in advanced heart failure: Differences across disease stages. Curr Heart Fail Rep. (2025) 22:18. doi: 10.1007/s11897-025-00705-0

17. Wang Y, Wu Z. The impact of fear of progression on return-to-work readiness among young and middle-aged patients with chronic heart failure. Prev Treat Cardio-Cerebrovasc Dis. (2022) 22:80–2. doi: 10.3969/j.issn.1009-816x.2022.03.021

18. Xiong J. Influencing Factors of Fear of Progression in Patients With Chronic Heart Failure and Longitudinal Study of Short-Term Readmission Events. Yangzhou (JS: Yangzhou University; (2023). master’s thesis.

19. Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, et al. PRISMA extension for scoping reviews (PRISMA-ScR): Checklist and explanation. Ann Intern Med. (2018) 169:467–73. doi: 10.7326/M18-0850

20. Arksey H, O’Malley L. Scoping studies: towards a methodological framework. Int J Soc Res Methodol. (2005) 8:19–32. doi: 10.1080/1364557032000119616

21. Peters MDJ, Marnie C, Tricco AC, Pollock D, Munn Z, Alexander L, et al. Updated methodological guidance for the conduct of scoping reviews. JBI Evid Synth. (2020) 18:2119. doi: 10.11124/JBIES-20-00167

22. Xiang Q, Xiong X, Zhang M, Liu S, Chen H, Liu M, et al. Incidence and influencing factors of kinesiophobia in patients with chronic heart failure: a scoping review. Front Psychol. (2024) 15:1395199. doi: 10.3389/fpsyg.2024.1395199

23. Aromataris E, Lockwood C, Porritt K, Pilla B, Jordan Z. JBI Manual for Evidence Synthesis. Adelaide (SA: JBI; ) (2024) p. 442–62. Available online at: https://synthesismanual.jbi.global (Accessed January 25, 2026).

24. Zhong H, Yuqing S, Liu Q, Chen H. Factors influencing eHealth literacy worldwide: Systematic review and meta-analysis. J Med Internet Res. (2025) 27:e50313. doi: 10.2196/50313

25. Du P, Kan L. Mediating effect of self-efficacy in the relationship between social support and fear of progression among CHF patients. Mod Prev Med. (2021) 48:4413–6.

26. Cao Y, Sun G, Liu J, Wang J, Chen N, Huang Y, et al. Current status and influencing factors of fear of progression in patients with chronic heart failure. J Bengbu Med Univ. (2022) 47:1760–4. doi: 10.13898/j.cnki.issn.1000-2200.2022.12.032

27. Zhao J, Jiao J, Shen H, Wang H. Construction of the risk prediction nomogram model for fear of progression in elderly patients with chronic heart failure. Pract J Card Cerebr Pneumal Vasc Dis. (2023) 31:17–21. doi: 10.12114/j.issn.1008-5971.2023.00.301

28. Hu S, Wang W, Wu Y, Guo W, Liu J, Zhang X, et al. Analysis of status and influencing factors of fear of progression in patients with chronic heart failure. J Qilu Nurs. (2024) 30:101–4. doi: 10.3969/j.issn.1006-7256.2024.09.030

29. Huang C, Ma H, Wang L, Qian R, Liu S, Li T. The correlation between sleep quality and fear of progression among patients with chronic heart failure. Mod Nurs. (2024) 31:116–9. doi: 10.19793/j.cnki.1006-6411.2024.27.028

30. Tang Q, Ma H, Yan Y, Chen X, Jiang W, He J. Potential profile analysis and influencing factors of fear of progression in patients with heart failure at the vulnerable stage. Pract J Card Cerebr Pneumal Vasc Dis. (2024) 32:118–23. doi: 10.12114/j.issn.1008-5971.2024.00.258

31. Zhu X, Zhou Y, Wang P, Hou J, Wang X, Huang Q, et al. Influencing factors of latent classes of fear of progression and correlation with symptom burden in elderly patients with chronic heart failure. J Clin Pathol Res. (2024) 44:1654–62. doi: 10.11817/j.issn.2095-6959.2024.240974

32. Cao M. Fear of Progression in Chronic Heart Failure: Current Status and Development of an Intervention Program. Jinan (SD: Shandong University of Traditional Chinese Medicine; (2025). master’s thesis.

33. Chen C, Sun X, Zhang Y, Xie H, Kou J, Zhang H. Fear of progression and quality of life in patients with heart failure: a cross-sectional study on the multiple mediation of psychological distress and resilience. BMC Nurs. (2025) 24:60. doi: 10.1186/s12912-025-02688-8

34. Tian L, Tian Y, Sun P, Feng C, An X, Du S. Social support and resilience as mediating factors in the link between illness perception and fear of progression among older patients with chronic heart failure: A multiple mediator model. Geriatr Nurs. (2025) 65:103521. doi: 10.1016/j.gerinurse.2025.103521

35. Li Y, Li J, Qin J, Zhou S, Gong K. Mediating effect analysis of social connectedness between fear of progression and sleep quality in patients with chronic heart failure. Clin Nurs Res. (2025) 34:223–33. doi: 10.1177/10547738251344666

36. Ma X, Guo C. Fear of progression in elderly patients with chronic heart failure: Current status and influencing factors. Chin J Integr Med Cardio-Cerebrovasc Dis. (2025) 23:129–33. doi: 10.12102/j.issn.1672-1349.2025.01.021

37. Qu L. The Influence of Fear of Progression on Self-Management and its Mediating Effect in Patients With Chronic Heart Failure. Dalian (LN: Dalian Medical University; (2024). master’s thesis.

38. Sun L, Wang M, Duan L, Zhu Y. Using the latent growth model to reveal the progression trajectory and key variables of fear of disease in chronic heart failure patients. Chin Gen Pract Nurs. (2025) 23:3633–9. doi: 10.12104/j.issn.1674-4748.2025.19.006

39. Tang Y, Zhang X, Yang Q, Zhang X. Mediating role of cognitive appraisal and benefit-finding in the relationship between fear of progression and quality of life in patients with chronic heart failure. Chin Ment Health J. (2025) 39:943–8. doi: 10.3969/j.issn.1000-6729.2025.11.03

40. Xu X, Gao H, Zhang F. Construction and validation of a predictive model for fear of progression and psychological dysfunction in patients with chronic heart failure. Psychol Mag. (2025) 20, 64–6. doi: 10.19738/j.cnki.psy.2025.19.016

41. Mehnert A, Herschbach P, Berg P, Henrich G, Koch U. Fear of progression in breast cancer patients - validation of the short form of the Fear of Progression Questionnaire (FoP-Q-SF). Z Psychosom Med Psychother. (2006) 52:274–88. doi: 10.13109/zptm.2006.52.3.274

42. Herschbach P, Berg P, Dankert A, Duran G, Engst-Hastreiter U, Waadt S, et al. Fear of progression in chronic diseases psychometric properties of the Fear of Progression Questionnaire. J Psychosom Res. (2005) 58:505–11. doi: 10.1016/j.jpsychores.2005.02.007

43. Hinz A, Mehnert A, Ernst J, Herschbach P, Schulte T. Fear of progression in patients 6 months after cancer rehabilitation-a- validation study of the fear of progression questionnaire FoP-Q-12. Support Care Cancer. (2015) 23:1579–87. doi: 10.1007/s00520-014-2516-5

44. Kwakkenbos L, van den Hoogen FHJ, Custers J, Prins J, Vonk MC, van Lankveld WGJM, et al. Validity of the Fear of Progression Questionnaire-Short Form in patients with systemic sclerosis. Arthritis Care Res (Hoboken). (2012) 64:930–4. doi: 10.1002/acr.21618

45. Wu Q, Ye Z, Li L, Peiyu L. Reliability and validity of Chinese version of Fear of Progression Questionnaire-Short Form for cancer patients. Chin J Nurs. (2015) 50:1515–9. doi: 10.3761/j.issn.0254-1769.2015.12.021

46. Herrmann J, Herzog K, Martini J, Santel A, Kulisch LK, Kühl J, et al. Fear of progression in pediatric cancer patients and their parents: Trajectories, prevalence, and correlates across acute treatment and follow‐up care. Psychooncology. (2026) 35:e70514. doi: 10.1002/pon.70514

47. Yang Z, Chen C, Wang M, Yang Y, Xu L. Prevalence and factors influencing fear of disease progression in stroke patients: a systematic review and meta-analysis with a focus on China. BMJ Open. (2025) 15:e091605. doi: 10.1136/bmjopen-2024-091605

48. Lowrance SA, Ionadi A, McKay E, Douglas X, Johnson JD. Sympathetic nervous system contributes to enhanced corticosterone levels following chronic stress. Psychoneuroendocrinology. (2016) 68:163–70. doi: 10.1016/j.psyneuen.2016.02.027

49. Harris KM, Jacoby DL, Lampert R, Soucier RJ, Burg MM. Psychological stress in heart failure: A potentially actionable disease modifier. Heart Fail Rev. (2021) 26:561–75. doi: 10.1007/s10741-020-10056-8

50. Addis SG, Dires A, Goshiye D, Girma M, Zeleke M, Haile D, et al. Fear of disease progression and related factors among chronic disease patients attending South Wollo zone government hospitals. Sci Rep. (2025) 16:140. doi: 10.1038/s41598-025-28868-9

51. Li A. Development and preliminary application of a fear of disease progression scale for patients with acute myocardial infarction. Zhenjiang (JS: Jiangsu University; (2021). master’s thesis.

52. Clarke ST, Murphy BM, Hester R, Jackson AC. Fear of recurrence and progression in people with heart disease: Risk factors and implications for emotional support. Behav Sci (Basel). (2025) 15:479. doi: 10.3390/bs15040479

53. Clarke ST, Le Grande M, Murphy BM, Hester R, Jackson AC. Protocol for the development and validation of a clinical measurement tool for fear of disease progression and recurrence in cardiac patients. Chronic Dis Transl Med. (2024) 10:195–204. doi: 10.1002/cdt3.115

54. He J, Xu H, Yang J, Hou D, Gong X, Lu X, et al. Fear of disease progression among breast cancer patients in China: A meta-analysis of studies using the fear of progression questionnaire short form. Front Psychol. (2023) 14:1222798. doi: 10.3389/fpsyg.2023.1222798

55. Liu X, Wang J, Dong H, Zhao Y, Liu L. Fear of disease progression in patients with type 2 diabetes construction and validation of a nomogram prediction model. Int J Gen Med. (2025) 18:4091–102. doi: 10.2147/IJGM.S531784

56. Wang Y, Yu Q, Zeng Z, Yuan R, Wang R, Chen J, et al. Predictors of fear of diabetes progression: A multi-center cross-sectional study for patients self-management and healthcare professions education. Front Public Health. (2022) 10:910145. doi: 10.3389/fpubh.2022.910145

57. Deng H, Yang T, Hu Y, Liu J, Chou H, Jiang Y, et al. Symptom clusters, fear of disease progression, and quality of life in postoperative gastric cancer patients: A cross-sectional study. Support Care Cancer. (2025) 33:219. doi: 10.1007/s00520-025-09180-8

58. Blum M, McKendrick K, Gelfman LP, Goldstein NE. Symptom burden in patients with advanced heart failure and its association with quality of life and activities of daily living. Qual Life Res. (2025) 34:485–93. doi: 10.1007/s11136-024-03823-9

59. Ding W, Lu J, Wang F, Bai L, Liu J, Wang R. Trends and influencing factors of self-management in patients with chronic heart failure: A longitudinal study. BMC Geriatr. (2025) 25:294. doi: 10.1186/s12877-025-05959-w

60. Li Y, Xiao T, Liao H, Qu H, Ren P, Chen X. Fear of progression, loneliness, and hope in patients with gastrointestinal cancer: A cross-sectional relational study. Front Psychol. (2024) 14:1279561. doi: 10.3389/fpsyg.2023.1279561

61. Guo K, Li H, Du W, Cheng L, Wang W, Zhou Z, et al. Patterns and predictors of post-traumatic growth and fear of disease progression in breast cancer patients: A latent profile analysis. Front Psychiatry. (2025) 16:1604787. doi: 10.3389/fpsyt.2025.1604787

62. Mallahzadeh A, Fereydoonnezhad T, Gauthier LV, Farjoud Kouhanjani M, Hosseinizadeh S, Khatibi A. Fear of disease progression and relapse in multiple sclerosis: A systematic scoping review. Front Psychiatry. (2025) 16:1680781. doi: 10.3389/fpsyt.2025.1680781

63. Luo S, Xiong Y, Song Z, Lian J, Qiu Y, Zhu M, et al. A cross-sectional study on fear of progression in patients with myasthenia gravis. Sci Rep. (2025) 15:26181. doi: 10.1038/s41598-025-11806-0

64. Murru V, Belfiori E, Sestu A, Casanova A, Serra C, Scuteri A. Patterns of comorbidities differentially impact on in-hospital outcomes in heart failure patients. BMC Geriatr. (2025) 25:371. doi: 10.1186/s12877-025-06002-8

65. Religioni U, Kupisz-Urbańska M, Niegowska W, Drab A, Czapski P, Januszewska-Mukarker K, et al. Self-efficacy and acceptance of illness among older patients with heart failure. Behav Sci (Basel). (2025) 15:679. doi: 10.3390/bs15050679

66. Sugiharto F, Nuraeni A, Trisyani Y, Putri AM, Armansyah NA, Zamroni AH. A scoping review of predictors associated with self-efficacy among patients with coronary heart disease. Vasc Health Risk Manag. (2023) 19:719–31. doi: 10.2147/VHRM.S435288

67. Rashid S, Qureshi AG, Noor TA, Yaseen K, Sheikh MAA, Malik M, et al. Anxiety and depression in heart failure: An updated review. Curr Probl Cardiol. (2023) 48:101987. doi: 10.1016/j.cpcardiol.2023.101987

68. Nuraeni A, Sugiharto F, Anna A, Sari E, Mirwanti R, Trisyani Y, et al. Self-efficacy in self-care and its related factors among patients with coronary heart disease in Indonesia: A Rasch analysis. Vasc Health Risk Manag. (2023) 19:583–93. doi: 10.2147/VHRM.S427488

69. Lebel S, Mutsaers B, Tomei C, Leclair CS, Jones G, Petricone-Westwood D, et al. Health anxiety and illness-related fears across diverse chronic illnesses: A systematic review on conceptualization, measurement, prevalence, course, and correlates. PloS One. (2020) 15:e0234124. doi: 10.1371/journal.pone.0234124

Associated Data

Supplementary Materials

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты