Giant, High-Grade Chondrosarcoma of The Hand: A Rare Case with Exceptional Tumor Size and Review of The Literature.

Chondrosarcoma is a malignant tumor originating from cartilage-producing cells. Although rare in the hand, it is the most common primary malignant bone tumor in this location. We present a case of high-grade chondrosarcoma of the first metacarpal bone in an 85-year-old female, who presented with pain and severe limitation of hand function. Imaging studies initially suggested a giant cell bone tumor, and a tru-cut biopsy did not confirm chondrosarcoma. During the preoperative period, the tumor enlarged from approximately 10x9 cm to 15x11 cm, ultimately necessitating amputation as the treatment of choice. Histopathological evaluation revealed grade 2-3 chondrosarcoma. According to the existing literature, a hand chondrosarcoma of this size has not been previously documented. Hand chondrosarcomas, unlike those in other regions, rarely metastasize; however, despite their low metastatic potential, they may still lead to substantial morbidity. When wide resection and amputation are performed, as in our case, the risk of local recurrence is significantly reduced.