Nihon juigaku zasshi. The Japanese journal of veterinary science · 1989
Biological effects of lipopolysaccharide from Achromobacter stenohalis on lymphocytes and macrophages.
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Isogai H, Isogai E, Fujii N, Oguma K, Chang K L, Deguchi E, Takano K, Hayashi M, Namioka S
Аннотация
The immunopotentiating activities of lipopolysaccharide from Achromobacter stenohalis (A-LPS) were examined. A-LPS was structurally atypical and gave no endotoxin shock in A-LPS-inoculated mice. Analysis in vitro showed that A-LPS was a potent activator of both macrophages and B-lymphocytes. After macrophage stimulation with A-LPS, interleukin-1 (IL-1) secretion, interferon (IFN) production and chemiluminescence (CL) response were induced. A-LPS was a potent mitogen for spleen lymphocytes. However, induction of interleukin-2 (IL-2) secretion in T lymphocytes was not observed. These activities of A-LPS were similar to or higher than that of enterobacterial LPS.